The lower second substitution activation energy for our lithium reagent (negative [DELTA][DELTA]E) and the higher second step for our Grignard reagent
(positive [DELTA][DELTA]E) supports the experimental findings where organolithium reagents are only capable of producing the disubstituted product.
For example, in the reaction of methyl benzoate and three equivalents of isopropyl Grignard reagent
, the desired diaklylated adduct yield was 32%.
The monosolvated Grignard reagent
in toluene is particularly liable to complexation with a silane.
The symmetrical derivatives were prepared from the corresponding Grignard reagent
A long-standing problem associated with Grignard reagent
synthesis is that, in order to facilitate reaction between the organic halide and the metal in an ether solvent, all of the reagents must be dry and the surface of the magnesium must be clean and oxide free.
2] anions also result when the neutral precursors are treated with an equimolar amount of a Grignard reagent
[Figure 3(b)], thereby indicating the occurrence of at least some single-electron transfer during these latter reactions.
Among the topics are solid-phase reactions of polymer-bound arenesulfonates with aryl Grignard reagents
, resin-to-resin transfer reactions through Sonogashira coupling, polyaniline-immobilized palladium for Suzuki-Miyuaura coupling reactions in water, solid-phase reactions of resin-supported boronic acids, and the palladium-catalyzed solid-phase synthesis of allelic amines.
She had the opportunity to present a poster regarding the use of grignard reagents
in ionic liquids and polymers, both of which are non-traditional, greener solvents.
Steroidal-4-en-3-ones such as 4-cholesten-3-one were treated with ozone to obtain a keto acid, 3,5-seco-4-norcholestan-5-on-3-oic acid (I), subsequently treated with amines to obtain enamine lactams which were discovered to react with Grignard reagents
at elevated temperatures to yield novel unsaturated 3-alkyl derivativatives.