gyrase


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gyrase

(ˈdʒaɪˌreɪz)
n
(Biology) biology a topoisomerase enzyme
References in periodicals archive ?
8) Quinolones act by inhibiting the action of type II topoisomerases, DNA gyrase and topoisomerase IV.
Fluroquinolones are potent DNA gyrase inhibitor causing bactericidal action (Prescott and Baggot, 1994) is active against most of gram positive and gram negative bacteria.
Reduced susceptibility to the fluoroquinolones group of antibiotics is usually linked with point mutations in the bacterial target genes gyrA, gyrB encoding DNA gyrase and/or parC, parE encoding DNA topoisomerase IV.
Plasmid-mediated protects from DNA quinolone gyrase binding resistance Overproduction Chromosomal genes Sulfonamides DHPS (5) feIP of target site produce excess Trimethoprim DHFR(6) foIA enzyme; compete with para-aminobenzoic acid.
They said antibiotic molecule, simocyclinone D8 (SD8), slots into pockets in the surface of a bacterial enzyme, DNA gyrase, and inhibits its activity.
Quinolones have a bactericidal effect when these bind with two target enzymes, DNA gyrase and topoisomerase IV, which are essential for DNA replication within the cell.
Quinolone antimicrobials, such as ciprofloxacin, levofloxacin, and norfloxacin act by inhibiting the gyrase or topoisomerase IV enzymes in S.
Two examples of receptor (target) modification are (a) mutations in RNA polymerase and DNA gyrase, rendering rifamycins and quinolones inactive (Heep et al.
DNA gyrase catalyses the negative supercoiling of DNA in bacteria and consists of two A subunits, encoded by gyrA, and two B subunits, encoded by gyrB.
Molecular studies indicated that the isolates had identical mutations in the genes encoding DNA gyrase (gyrA) and topoisomerase IV (parC), mutations associated with fluoroquinolone resistance.
The primary mechanism of action of quinolone antibiotics is inhibition of the bacterial enzyme DNA gyrase.
Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant Shigella dysenteriae serotype 1 clinical isolates from Kolkata, India.