HLA


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HLA

abbr.
human leukocyte antigen

HLA

human leukocyte antigen: any of a complex of genetically determined antigens, occurring on the surface of almost every human cell, by which one person's cells can be distinguished from another's and histocompatibility established.
[1970–75]
References in periodicals archive ?
We are obliged to Rheumatologists and orthopaedic surgeons for sending us patients for HLA B27 testing.
We selected polymerase chain reaction-sequence specific primers for HLA genotyping, which was performed using Polymerase Chain Reaction-Sequence Specific Oligonucleotides Microspheres Fluor analyzer (Luminex Corp.
Increased frequency of HLA DRB*12 and HLA-DRB1*03 has been reported in asthma patients in Pakistan and pediatric asthmatics of Indian population respectively (Javaid et al.
Recent guidelines from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) for the diagnosis and treatment of celiac disease recommend that HLA testing for CD should be offered to asymptomatic children and adolescents if they carry an increased risk for CD such as in autoimmune thyroiditis.
Human leukocyte antigen (HLA) loci including HLA-A, -B, -C, -DR, -DQ, and -DP individually along with HLA haplotypes which are comprised HLA loci as a DNA string on one chromosome have been found to be associated with many diseases with autoimmune disorders, such as ankylosing spondylitis (AS),[sup][1],[2] type 1 diabetes,[sup][3],[4],[5],[6],[7],[8],[9] inflammatory bowel disease,[sup][10],[11],[12] with strong association between HLA-B27 and AS being the typical example.
Because of the lower throughput of the available technologies and to reduce the number of polymorphic sites to interrogate, early molecular strategies for clinical HLA typing focused on characterization of the antigen recognition site only (exons 2 and 3 for class I; exon 2 for class II).
Clinical profile and HLA typing of autoimmune hepatitis from Pakistan.
When external force is applied to the lash adjuster, the internal fluid supply is checked and the resulting fluid pressure within the HLA prevents the plunger form collapsing, thereby transmitting the camshaft motion into valve lift.
The ubiquitously expressed transmembrane class I HLA molecule is a heterodimer consisting of a highly polymorphic heavy (a) chain that is linked to the [[beta].
Large multicentric studies (9) have shown that there is a significant beneficial influence of HLA matching/typing on the graft outcome.
Those related to ensure the immunological compatibility include blood group compatibility; negative T and B cell complement-dependent cytotoxicity crossmatch test using donor lymphocytes as target cells; negative screening test to detect recipient reactive antibodies against HLA antigens; and compatibility between the donor and recipient HLA genes.
Few studies reported an association between HLA markers and toxoplasmic encephalitis in AIDS patients.