Two of the following three criteria characterize the syndrome: two or more hamartomatous
polyps in the GI tract; mucocutaneous hyperpigmentation of the mouth, lips, nose, eyes, genitalia, or fingers; and a family history of Peutz-Jeghers syndrome.
AMLs are benign hamartomatous
tumors that rarely occur in extrarenal locations.
Signal characteristics of these nodules are similar to mature white matter, differentiating these hamartomatous
lesions from heterotopic gray matter, an additional developmental lesion implicated in chronic epilepsy.
PJS is characterized by hamartomatous
gastrointestinal polyposis and hyperpigmentation of the skin and mucous membranes and is associated with an increased risk of both intestinal and extraintestinal malignancies.
1998) Criteria Age at Onset Major Facial angiofibroma Infancy to adulthood Ungual fibroma Adolescence to adulthood Shagreen patch Childhood Hypomelanotic macule Infancy to childhood Cortical tuber Fetal life Subependymal nodule Childhood to adolescence Subependymal giant Childhood to adolescence cell tumor Retinal hamartoma Infancy Cardiac rhabdomyoma Fetal life Renal angiomyolipoma Childhood to adulthood Lymphangioleiomyomatosis Adolescence to adulthood Minor Multiple pits in dental enamel Hamartomatous
rectal polyps Bone cysts Cerebral white-matter radial migration lines Gingival fibromas Nonrenal hamartoma Retinal achromic patch "Confetti" skin lesions Multiple renal cysts Note.
epithelial, lymphoid and germ cell neoplasms; thymic cysts; hyperplasia; and hamartomatous
Background and Design: Becker nevus (BN), characterized by sharply and irregularly bordered, unilaterally localized, hyperpigmented macules and patches which can go along with hypertrichosis, is a kind of hamartomatous
lesion that predominantly affects males 4-6 times more frequently than females.
TS is characterised by hamartomatous
lesions involving multiple organs.
We speculate that both bladder diverticulum in the dome and the component of hamartomatous
angiomyolipoma in our case was a result of embryogenic malformation.
It has been postulated that solitary neurofibroma is hyperplastic hamartomatous
malformations rather than a neoplastic disease .
Lisch nodules are pigmented hamartomatous
naevus, (11) which occur from proliferation of melanocytes and fibroblasts.
Colorectal (Peutz-Jeghers-type hamartomatous
polyps), gastric, pancreatic, breast, and ovarian cancers