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Hand-Schuller-Christian disease

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.13 sec.
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Noun1.Hand-Schuller-Christian disease - inflammatory histiocytosis associated with disturbance of cholesterol metabolism; occurs chiefly in young children and is characterized by cystic defects of the skull and diabetes insipidus
histiocytosis - a blood disease characterized by an abnormal multiplication of macrophages


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1) At that time, histiocytosis X was subdivided into three types: (1) eosinophilic granuloma, an isolated osteolytic lesion: (2) Hand-Schuller-Christian disease, a multifocal version of eosinophilic granuloma that is often accompanied by systemic manifestations; and (3) Letterer-Siwe disease, a systemic, rapidly progressive form of histiocytosis X.
 
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