Hand-Schuller-Christian disease

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Noun1.Hand-Schuller-Christian disease - inflammatory histiocytosis associated with disturbance of cholesterol metabolism; occurs chiefly in young children and is characterized by cystic defects of the skull and diabetes insipidus
histiocytosis - a blood disease characterized by an abnormal multiplication of macrophages
References in periodicals archive ?
INTRODUCTION: We wish to report a very rare case of hand-schuller-christian disease affecting both the twin male children of 6 years age .
In addition, multiple tumors can affect a single organ system (most often the skeleton); this type of presentation is given the eponym Hand-Schuller-Christian disease, and can require more aggressive therapy such as systemic chemotherapy, particularly if the bony lesions are in anatomically sensitive sites.
Hand-schuller-christian disease is a rare entity comprising of exophthalmos, diabetes insipidus and geographic map skull.