CRM197 is a well defined protein and functions as a carrier for polysaccharides and haptens
making them immunogenic.
Among their topics are the molecular recognition of haptens
by T cells, Langerhans cell migration and the induction phase of skin sensitization, and the multiple roles of keratinocytes in ACD.
Several studies with cells from human eczema lesions delivered experimental evidence for the presence of Thl7 in ACD and isolated Thl7 cells lines released significant amounts of IL-17 in response to chemical haptens
It is also possible that methamphetamines alter self-proteins, making them immunogenic or creating haptens
Researchers found that 25% of participants were producing antibodies against various chemicals, indicating chronic exposure to chemical haptens
Filaggrin deficiency confers a paracellular barrier abnormality that reduces nflammatory thresholds to irritants and haptens
The structure of such haptens
makes interaction with 2 binding proteins (e.
This phenomenon is clinically well known as anergy to tuberculin or other immunogenic haptens
after subcutaneous injections.
8) LMW allergens acting as haptens
form complexes with proteins that are recognised by the immune system, leading to the ensuing allergic response.
Reactive intermediate products which form as a result of metabolism in the liver or in another place act as haptens
and bind to high molecular weight proteins (3).
The dogma that "small" organic molecules (that is, molecules of molecular weights of less than about 1000 Daltons) need to be presented as haptens
bound to a macromolecular carrier (151) to be immunogenic may not always hold true (135), but in any case, morphine at least may bind to serum proteins (114) and numerous laboratory studies have demonstrated ready formation of immunoglobulin G and immunoglobulin M antibodies to protein-coupled opioids (152-164).
Offering classical and new techniques, they also cover a number of disciplines as they address the molecular mechanisms of allergy, culture of T-cells from peripheral blood, T-cell lines and human T-cell clones, human T-cell epitopes of allergens, restriction of T-cell responses, short-term culture of CD8 cells and intracellular cytokine staining, processing of certain T-regulatory cells, using monocyte-derives dentritic cells and antigen-presenters in T-cell proliferation and cytokine production, human cytokine responses, human chemokine production, standardization and characterization of allergen extracts, conjugation of haptens
, monoclonal antibodies, air sample assays, hologene assays, microscopic identification of pollens, identification of mast cells, and in-situ hybridization.