(redirected from Haptens)
Also found in: Medical, Encyclopedia.
Related to Haptens: Epitopes


 (hăp′tĕn′) also hap·tene (-tēn′)
A small molecule that reacts with a specific antibody but does not induce an immune response unless bound to a larger molecule, usually a protein.

[German : Greek haptein, to fasten + German -en, noun suffix (from Greek -ēnē, -ene).]

hap·ten′ic adj.


(ˈhæptən) or


(Physiology) immunol an incomplete antigen that can stimulate antibody production only when it is chemically combined with a particular protein
[C20: from German, from Greek haptein to fasten]


(ˈhæp tɛn)

also hap•tene


a substance that reacts with antibodies but cannot by itself stimulate more antibodies; a partial antigen.
[1920–25; < German < Greek hápt(ein) to grasp + German -en -ene]
Mentioned in ?
References in periodicals archive ?
Allergic contact dermatitis (ACD) is a type IV delayed-type hypersensitivity reaction to haptens that come into contact with the skin.
To study the effect of HaCaT keratinocytes on the response of THP-1 cells to sensitizers, we exposed THP-1 cells for 24 h in the absence and presence of HaCaT cells to a set of 14 sensitizers (6 haptens, 1 pre- and 7 prohaptens).
Similar to Janda's antiheroin vaccine, haptens are bound to a protein carrier, spurring the immune system to create high levels of antibody to bind heroin and its metabolites in the blood and prevent it from crossing the blood-brain barrier.
1) ACD is generally induced by small compounds called haptens (less than 500 daltons of molecular weight).
3] have been observed in other animal models that used haptens to induce skin inflammation [38].
Once haptens or allergens enter the epithelia, DCs react to these antigens and stimulate the acquired immune response.
Haptens such as hormones, vitamins, drugs, and toxins play a wide variety of roles in biology, and accurate measurement of them is essential.
It is also possible that methamphetamines alter self-proteins, making them immunogenic or creating haptens.
Filaggrin deficiency confers a paracellular barrier abnormality that reduces nflammatory thresholds to irritants and haptens.
Diagram 1: How Food Sensitivities Cause Inflammation Mechanisms * TLR's * Food antigens * Food chemicals * Haptens * Amines * Pharmacologic * Immune Complexes * IgG * IgM * Lectins Cellular Activation * Lymphocytes * Sensitized T-cells * T-Cells * NK Cells * K Cells * Eosinophils * Basophils * Monocytes * Neutrophils Mediator Release * Cytokines * Interleukins * Chemokines * TNFs * Interferons * Leukotrienes * Histamine * ECP.
15) Photoallergic reactions occur when drug haptens combine with skin proteins and are affected by UVA producing a cell-mediated immune reaction.