| Harlem River A channel in New York City separating the northern end of Manhattan Island from the Bronx. With Spuyten Duyvil Creek it connects the Hudson and East rivers. |
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| Noun | 1. |  Harlem River - a channel separating Manhattan from the BronxGreater New York, New York, New York City - the largest city in New York State and in the United States; located in southeastern New York at the mouth of the Hudson river; a major financial and cultural center |
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