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homeobox
(redirected from Homeodomain protein)

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
homeobox  (hm--bks)
Any of various DNA sequences containing about 180 nucleotides that encode for corresponding sequences of usually 60 amino acids, called homeodomains, found in proteins that bind DNA and regulate gene transcription. Genes containing homeoboxes are found in all eukaryotic genomes and are associated with cell differentiation and bodily segmentation during embryologic development.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.homeobox - one of various similar homeotic genes that are involved in bodily segmentation during embryonic development
homeotic gene - one the genes that are involved in embryologic development


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LEDGF appears to be important during embryonic development, since the majority of homozygous LEDGF KO mice die perinatally and survivors display a range of abnormal phenotypes, compatible with defects in homeodomain proteins [84].
The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.
Selleri researches the developmental contributions of human proto-oncogenes with a focus on the biological functions of Pbx1, a homeodomain protein originally identified as the product of an oncogene in childhood leukemias.
 
 
 
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