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Homotypic |
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| After DENV-1 infection, homotypic neutralizing antibody titers increase, and heterotypic antibody titers to 1 of 2 genotypes of DENV-2 virus (the American genotype) decrease. Homotypic protection has been demonstrated for both vaccines, but the degree to which they cross-protect against less common G- and P-type combinations not included in the vaccine formulations has yet to be established, and the importance of genotype-specific protection against rotavirus disease is still under discussion (26,27). We evaluated titers of homotypic and heterotypic neutralizing antibodies (NAbs) to Andes and Sin Nombre hantaviruses in plasma samples from 20 patients from Chile and the United States. |
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