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Apresoline |
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Hydralazine hydrochloride has been associated with peripheral neuritis, evidenced by paresthesia, numbness and tingling, which may be related to an antipyridoxine effect. In addition, the company launched Hydralazine Hydrochloride, an existing generic, with estimated sales of $23 million in 2008 according to IMS data. A study published in the current edition of Clinical Pharmacokinetics, a peer-reviewed scientific journal, reports that two different combinations of individual isosorbide dinitrate (ISDN) and hydralazine hydrochloride (HYD), used in the Vasodilator-Heart Failure Trials (V-HeFT) I and II are not bioequivalent to BiDil([R]), the fixed-dose combination of ISDN and HYD, used in the African American Heart Failure Trial (A-HeFT). |
Hydralazine hydrochloride |
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