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hydrophobic
(redirected from Hydrophobic interaction)

   Also found in: Medical, Wikipedia, Hutchinson 0.04 sec.
hy·dro·pho·bic  (hdr-fbk)
adj.
1. Repelling, tending not to combine with, or incapable of dissolving in water.
2. Of or exhibiting hydrophobia.

hydro·pho·bici·ty (-bs-t) n.
ThesaurusLegend:  Synonyms Related Words Antonyms
Adj.1.hydrophobic - lacking affinity for water; tending to repel and not absorb water; tending not to dissolve in or mix with or be wetted by water
chemical science, chemistry - the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions
hydrophilic - having a strong affinity for water; tending to dissolve in, mix with, or be wetted by water
2.hydrophobichydrophobic - abnormally afraid of water
afraid - filled with fear or apprehension; "afraid even to turn his head"; "suddenly looked afraid"; "afraid for his life"; "afraid of snakes"; "afraid to ask questions"

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Hydrophobic interactions bind some proteins there, while hydrogen bonding or other forces attach yet other proteins to the hot spot.
Briefly, the ligand is trapped from the bulk solution at the entrance of the ligand-binding pocket and brought into and locked at the binding site by interaction with amino acid residues within the receptor through H-bond and hydrophobic interactions.
Even though results of these studies have at times been contradictory because no standardized methods exist for determining surface hydrophobicity, some kind of hydrophobic interaction apparently occurs between the cell surface and the substratum that would enable the cell to overcome the repulsive forces active within a certain distance from the substratum surface and irreversibly attach.
 
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