INTRODUCTION: Adult type hypolactasia
develops due to decreased activity of the enzyme lactase phlorizin hydrolase and stops its synthesis in mammals after the weaning period.
and calcium availability: decreased calcium intake or impaired calcium absorption?
Secondary causes of hypolactasia
should also be excluded, if the genotype is not in concordance with LHBT, in order to complete the diagnosis of lactose intolerance.
The first is known as primary adult-type hypolactasia
Genetic and epidemiology of adult-type hypolactasia
Comparison of a portable breath hydrogen analyser (Micro H2) with a Quintron MicroLyzer in measuring lactose maldigestion, and the evaluation of a Micro H2 for diagnosing hypolactasia
A biopsy-based quick test in the diagnosis of duodenal hypolactasia
in upper gastrointestinal endoscopy.
Walter Reed Army Medical Center in Washington, and the University of Maryland, Baltimore, attempted to identify organic gastrointestinal findings among 323 patients with IBS who received an extensive array of tests: complete blood count, comprehensive metabolic panel, thyroid function test, erythrocyte sedimentation rate, C-reactive protein panel, inflammatory bowel disease panel, hypolactasia
(lactase deficiency) genetic assay, celiac disease panel, and colonoscopy with rectosigmoid biopsies.
A rise in the hydrogen level of more than 20 parts per million (ppm) over baseline suggests hypolactasia
To look for hints that this sugar might also affect fecundity, his team compared published data from 36 countries on rates of fertility, per capita milk consumption, and hypolactasia
- that adult inability to digest lactose.
A number of validated clinical assays are available for diagnosis of genetic diseases such as Prader-Willi/Angelman syndromes, adult hypolactasia
, and multiple polymorphisms in the APOE gene, as well as tests to characterize the complex cancer mutations involved in multiple endocrine neoplasia type 2.
BACKGROUND: Approximately 70% of the world population has hypolactasia
, which often remains undiagnosed and has the potential to cause some morbidity.