myelofibrosis

(redirected from Idiopathic myelofibrosis)
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Related to Idiopathic myelofibrosis: primary myelofibrosis

my·e·lo·fi·bro·sis

 (mī′ə-lō-fī-brō′sĭs)
n.
Proliferation of fibroblastic cells in bone marrow, causing anemia and sometimes enlargement of the spleen and liver.

myelofibrosis

(ˌmaɪələʊfaɪˈbrəʊsɪs)
n
(Pathology) a disorder which causes fibrosis of the bone marrow

my•e•lo•fi•bro•sis

(ˌmaɪ ə loʊ faɪˈbroʊ sɪs)
n.
the replacement of bone marrow by fibrous tissue, characteristic of leukemia and certain other diseases.
[1945–50]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.myelofibrosis - fibrosis of the bone marrow
fibrosis - development of excess fibrous connective tissue in an organ
Translations

my·e·lo·fi·bro·sis

n. mielofibrosis, fibrosis de la médula ósea.

myelofibrosis

n mielofibrosis; primary — mielofibrosis primaria
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References in periodicals archive ?
Although Turner Syndrome is well known for its cardiovascular, renal, endocrinologic and reproductive complications,7 cases of Turner Syndrome associated with haematologic anomalies are very rare and only few were reported for example, case of Turner syndrome with T-large granular lymphocyte leukaemia (T-LGL), one with coexistence of chronic lymphocytic leukaemia (CLL) and idiopathic myelofibrosis (IMF) and one with AML-M2.
Patients and Methods: Ninety three consecutive patients of Polycythaemia vera (PV), Essential thrombocythaemia (ET) and Idiopathic myelofibrosis (IMF) diagnosed by the conventional haematological criteria were included in the study.
Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis.
I would like to make few comments on Balci and her colleagues' paper entitled "Complex cytogenetic findings in the bone marrow of a chronic idiopathic myelofibrosis patient" which was published in the recent issue of the Journal.
The aspirate smears showed 4% blasts and the biopsy specimen showed 40% cellular bone marrow clusters of dysplastic megakaryocytes, dilated sinusoids, and grade 2/4+ fibrosis, consistent with idiopathic myelofibrosis (also known as agnogenic myeloid hyperplasia).
Chronic myeloproliferative disorders (CMPDs) are clonal haematopoietic stem cell disorders and include the BCR-ABL negative CMPDs like polycythemia vera (PV), essential thrombocythemia (ET), idiopathic myelofibrosis (IMF) and chronic eosinophilic leukaemia (CEL) (1,2).
S*BIO Pte Ltd, Singapore, has announced the initiation of a Phase 1/2 clinical trial of SB1518, a potent and orally-active JAK2 inhibitor, in leading medical centers in Australia for patients with chronic idiopathic myelofibrosis (CIMF).
Differential diagnosis The differential diagnosis of MCL in the bone marrow includes HCL, idiopathic myelofibrosis, Hodgkin's disease, hypergranular AML-M5 and CML.
Herein, we report a case of idiopathic myelofibrosis of a 6-year old male patient who presented with complaints of pallor, petechiae and bleeding from gums.
Chronic idiopathic myelofibrosis is a myeloproliferative disorder characterized by splenomegaly, myeloid metaplasia and reactive bone marrow fibrosis.

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