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Any of the epitopes (antigenic determinants) that are found in the variable region of a particular immunoglobulin molecule and together make up the molecule's idiotype.

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To obtain insight into the remarkable immunogenicity of the 3-FL determinant in mice, we examined the occurrence of anti-3-FL antibodies and crossreactive idiotopes in the sera of unimmunized and immunized mice.
The immune network theory suggests that the receptor molecules contained in the surface of the immune cells present idiotopes, and these idiotopes are displayed in and/or around the same portions of the receptors that recognize non-self antigens.
They may, however, show activity against idiotopes, which are not present in nonimmune globulin (8), or against conjugated detector antibodies (8,18).
Although allotypic epitopes can be expressed by many IgG molecules independent of their isotype, idiotopes that are formed by the variable region on the Fab portion mostly are unique epitopes.