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penetrance
(redirected from Incomplete penetrance)

   Also found in: Medical, Encyclopedia, Wikipedia 0.03 sec.
pen·e·trance  (pn-trns)
n.
The frequency, under given environmental conditions, with which a specific phenotype is expressed by those individuals with a specific genotype.

penetrance [ˈpɛnɪtrəns]
n
(Life Sciences & Allied Applications / Genetics) Genetics the percentage frequency with which a gene exhibits its effect
[from penetr(ant) + -ance, on the model of German penetranz]


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In recent years, however, geneticists have begun to suspect that Hirschsprung's disease follows a pattern called autosomal dominance with incomplete penetrance.
The condition affects 1:2,000 to 1:10,000 newborns and is passed to offspring as a mendelian recessive with incomplete penetrance.
Paigen, the Jackson Laboratory scientist who directs Nishina and Naggert's research, says a genetic phenomenon called incomplete penetrance could account for the fact that myocardial infarctions strike mostly men and postmenopausal women.
 
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