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Interfollicular |
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In`ter`fol`lic´u`lar
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| Germinal center formation is commonly seen in the lymphoid component, but a true lymph node architecture with sinus formation, a medullary region, or interfollicular zones is absent. Leibenhaut et al studied 915 patients with clinical stage (CS) I and II Hodgkin's disease who underwent laparotomy, and they were able to identify specific subgroups in whom laparotomy had a low yield [14] These patients included women with CS I disease, patients with mediastinum-only CS I disease, and men with CS I disease who had either lymphocyte predominance or interfollicular histologies. Low-power view (A) of the lymph node biopsy specimen reveals the presence of follicular hyperplasia and proliferating blood vessels in the interfollicular region (H&E, original magnification x 40). |
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