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Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
References in periodicals archive ?
Interleukin-18 (IL-18), secreted by antigen presenting cells such as macrophages and dendritic cells, is a T helper 1 (Th1) cytokine which plays an important role in the activation of Th1 immune response.
Increased mRNA expression of interleukin-1[sz], interleukin-18, and NOD-like receptor family, pyrin domain containing 3 in muscle tissue of dermatomyositis/polymyositis patients
actinomycetemcomitans were used to infect human mononuclear leukocytes, only up-regulation of NLRP3, interleukin- 1[beta], interleukin-18 and reduction of NLRP6 were observed.
Abbreviations I/R: Ischemia and reperfusion ROS: Reactive oxygen species NLRP3: NOD-like receptor family pyrin domain containing 3 LOX: Lipoxygenase COX: Cyclooxygenase TRX: Thioredoxin CAT: Catalase PRRs: Pattern-recognition receptors PAMPs: Pathogen-associated molecular patterns DAMPs: Damage-associated molecular patterns TLRs: Toll-like receptors RLRs: RIG-I-like receptors NF-[kappa]B: Nuclear Factor kappa-light-chain-enhancer of activated B cells NLRs: Nod-like receptors ALRs: AIM2-like receptors CLRs: C-type lectin receptors IL-1[beta]: Interleukin-1[beta] IL-18: Interleukin-18 TXNIP: TRX-interacting protein SOD: Superoxide dismutase GPx: Glutathione peroxidase MDA: Malondialdehyde KO: Knock-out BBG: Brilliant Blue G.
Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.
A case of refractory adult-onset Still's disease with high serum Interleukin-18 levels treated with monitoring of serum levels of cyclosporine.
The interleukin-6 (IL-6) and interleukin-18 (IL-18) concentrations were measured in the serum by Enzyme linked immunosorbent assay.
Similarly, interleukin-18 (IL-18), a cytokine involved in innate and adaptive immunity, has emerged as a promising biomarker predictive of mortality in critically ill patients with AKI (9).
Interleukin-18 (IL-18) is an important proinflammatory cytokine, member of the Interleukin-1 (IL-1) cytokine family, which has been shown to exert innate and acquired immune responses [11,12].
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, plays an important regulatory role in inflammation and pathogenic processes of allergic diseases, as well as reproduction and immunoregulation.