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Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
References in periodicals archive ?
11, 2015 /PRNewswire/ --Summary DelveInsight's, Interleukin-18 (IL-18) Inhibitors- Pipeline Insights, 2015, provides the in-depth analysis of the pipeline assets across the Interleukin-18 (IL-18) Inhibitors.
A case of refractory adult-onset Still's disease with high serum Interleukin-18 levels treated with monitoring of serum levels of cyclosporine.
Similarly, interleukin-18 (IL-18), a cytokine involved in innate and adaptive immunity, has emerged as a promising biomarker predictive of mortality in critically ill patients with AKI (9).
Interleukin-18 (IL-18) is an important proinflammatory cytokine, member of the Interleukin-1 (IL-1) cytokine family, which has been shown to exert innate and acquired immune responses [11,12].
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, plays an important regulatory role in inflammation and pathogenic processes of allergic diseases, as well as reproduction and immunoregulation.
Plasma levels of interleukin-18, for example, have been shown to be strongly associated with ulcerative colitis activity, as evaluated through clinical and endoscopic scoring systems and CRP levels.
Citrus flavonoids may lower one's markers of inflammation, particularly interleukin-18 (IL-18).
1 Urine myoglobin, [micro]g/L 39,900 NT 2,500 Urine erythrocytes 3+ 3+ [+ or -] Serum interleukin-18, pg/mL 612 519 NT Serum tumor necrosis factor--[alpha], pg/mL 3.
Serum Levels of Interleukin-18 are Reduced by Diet and n-3 Fatty Acid Intervention in Elderly High-Risk Men Metabolism 58(11), 1543-1549 (2009).
Interleukin-18 also is prominent in chronic intestinal inflammation associated with autoimmune disorders, such as inflammatory bowel disease.
There were also increased levels of interleukin-18, a cytokine produced by macrophages and associated with strong inflammatory reactions and tissue destruction.
It has also been demonstrated that resting healthy human muscles express cytokines in a fiber type specific manner, such as tumor necrosis factor (TNF)-alpha and interleukin-18 (IL-18) is solely expressed by type II fibers, whereas the expression of IL-6 in more prominent in type I compared to type II fibers (Plomgaard et al.