Electron microscopy found cytoplasmic whorls of intermediate filaments
, some of which displaced the nucleus (Figure 3).
The intermediate filaments
are assembled from keratin monomers and the cornified envelope is assembled from a protein called involucrin and several other proteins.
When perturbed, it produces copious amounts of thick slime made of mucus reinforced with long threads of proteins called intermediate filaments
(IF); these proteins are also found in the cytoskeleton of all cells.
9] Cytokeratin (CK) intermediate filaments
are part of the cytoskeleton of epithelial cells.
Tumor cells usually contain intermediate filaments
, have cell junctions, and may contain glycogen, dense core granules, and neurotubles.
Neoplastic cells were positive for vimentin and negative for desmin and actin and showed ultrastructural features (dilated stacks of rough endoplasmic reticulum, intermediate filaments
, rare collagen secretion granules, lack of external lamina) typical of fibroblasts.
(IFs) participate in key mechanical functions and play a role in preventing excess large cell stretch.
It consists mainly of intermediate filaments
called lamins and microfilaments cal led act ins and DNA topoisomeraseII (Fig.
Immunopathology Antibodies * Breast Cancer Markers * Cell Cycle Antigens * Cellular & Oncofetal Antigens * Endocrine Antigens * Enzyme Antigens * Hemapoietic Markers * Immunoglobulins * Infectious Agents * Intermediate Filaments
* Melanoma Panels * Multidrug Resistance Markers * Nephology/Urology Panels * Prognostic Markers * Tumor-Associated Markers Neuropathology Antibodies * Amyotrophic Lateral Sclerosis (ALS) * Alzheimer's Disease * Amyloidosis * Diffuse Axonal Injury * Huntington's Disease * Parkinson's Disease * Prion Diseases * Schizophrenia Detection
Now, Christine Jacobs-Wagner of Yale University and her colleagues report that crescentin forms strands resembling intermediate filaments
, which are yet another component of the skeleton in animal cells.