Isthmus of Panama

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Related to Isthmas of Panama: Bering Strait, Mariana Trench
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Noun1.Isthmus of Panama - the isthmus that connects Central America and South America; was formerly called the Isthmus of Darien; "Balboa crossed the Isthmus of Darien"
Panama, Republic of Panama - a republic on the Isthmus of Panama; achieved independence from Colombia in 1903