Analyzing DLX1 and HOXC6 biomarkers, using KLK3
expression as internal reference combined with age, DRE results, and PSA level, this test provides percent likelihood of having any prostate cancer and percent likelihood of having high-grade prostate cancer (Leyten et al.
A large-scale analysis of genetic variants in miRNA binding sites identified 22 prostate cancer risk associated miRSNPs, the 2 most significant miRSNPs being KLK3
(kallikrein related peptidase 3) rs1058205 (T>C) and VAMP8 (vesicle associated membrane protein 8) rs1010 (A>G), which were targeted by miR-3162-5p and miR-370-5p respectively in an allele specific manner (77).
Of note, the prostate-specific antigen (PSA [kallikrein3 protein; KLK3
, gene]) is expressed and secreted by human but not mouse luminal prostate cells, which secrete other proteins that seem to be lobe-specific [39, 40].
They analysed associations of the SNPs with disease aggression and found that the KLK3
gene can predict an aggressive form of GS7 disease.
encodes PSA was one of the six loci identified by GWAS that were associated with higher PSA levels in patients without prostate cancer .
x] emissions KLK2 Total PM emissions KLK3
The genes that were more highly expressed in carcinomas treated with androgen ablation agents included those encoding AR and steroid biosynthetic enzymes, as well as a suite of genes that have been previously shown to be targets of AR or have been implicated as being regulated by it, including the gene encoding PSA (kallikrein-related peptidase 3), KLK3
, and KLK2, as well as DBI, FASN, IL6, SERPINB5, TGFBR3, TMPRSS2, TUBA1, HOXC6, TRG ,and FOLH1.
PSA and human kallikrein 2 are closely related products of human kallikrein genes KLK3
and KLK2, respectively.
In the paper being published in The Journal of Biological Chemistry, Compugen's scientists report the identification of unusual mRNA splice variants of the KLK2 and KLK3
To address this question, we examined the relationship between SNPs in KLK2 and KLK3
and concentrations of hK2 and PSA in serum and seminal plasma by use of a population-based cohort of young men in whom prostate conditions are very rare.
Biomarker Official gene name (a) Clinical use [alpha]-fetoprotein AFP Staging (AFP) Human chorionic CGB Staging gonadotropin (hGC) Carbohydrate antigen Monitoring 19-9 (CA19-9) Carbohydrate antigen MUC16 Monitoring 125 (CA125) Carcinoembryonic PSG2 Monitoring antigen (CEA) Epidermal growth EGFR Prediction factor receptor (EGFR) v-kit KIT Prediction Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) Thyroglobulin TG Monitoring Prostate specific KLK3
Screening and antigen (PSA) monitoring Carbohydrate antigen MUC1 Monitoring 15.
PSA is encoded by KLK3
 (kallikrein-related peptidase 3), a member of a family of 15 kallikrein genes located on human chromosome 19 (4).