Asimismo, se han identificado otros genes que pueden participar activamente en el desarrollo de este sindrome, entre los que se encuentra DLX3, FAM83H, MMP-20, KLK4
y WDR72 (14).
16) Several genes have been implicated in the development of amelogenesis imperfecta, including AMELX, ENAM, DLX3, FAM83H, MMP20, KLK4
, and WDR72.
Among the topics are single nucleotide polymorphisms in the human kallikrein-related peptidase (KLK) locus and their implications in various diseases, molecular recognition properties of KLK on synthetic and endogenous substrates, KLK within the proteolytic web, the role of KLK4
in dental enamel formation, and physiological and pathophysiological roles of KLK in the central nervous system.
edu/exomeChip/Proposed Content/codingContent) have indicated the occurrence of stop codons in several KLK genes, including KLK4
, KLK9, KLK10, and KLK14.
2] emissions KLK4
Emissions to Emissions to soil and water KFV1 soil and water Waste generation KFV2 Table 3.
MONOCLONAL-POLYCLONAL ELISA CONFIGURATION, VERSION 1 (FOR KLK4
, 12, AND 14)
is up-regulated by androgens in prostate cancer cell lines (17) and by estrogens in endometrial cancer cell lines (16).
However, subsequent reverse transcription-PCR studies demonstrated that KLK4
mRNA is also expressed in other tissues, although at much lower concentrations than in the prostate (11,13 ).
An exception is one KLK4
isoform, which retains all of the residues of the catalytic triad but lacks the signal peptide and is thought to act intracellularly (21).
Previously, several other kallikreins, including KLK4
, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
is up-regulated by androgen in prostate and breast cancer cell lines (24) and by estrogen in endometrial cancer cell lines (25).
On the basis of the amino acid sequences, the closest relatives of KLK4
within the human kallikrein gene family are those that encode PSA (38% identity), the human stratum corneum chymotryptic enzyme (45% identity), and KLK6 (zyme/ neurosin/protease M; 38% identity) (6); the last and KLK10 are implicated in ovarian cancer (7, 8).