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kinase |
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Without a growth regulator, enzymes called kinases become overactive and cause the kidney cells to proliferate abnormally and to secrete fluids when they should be absorbing them, says study coauthor Oxana Ibraghimov-Beskrovnaya, a cell biologist at Genzyme Corp. Specifically, Enamine will create a compound library of kinases, which are related to cancer. Defects in specific protein kinases have been linked to over 400 diseases including cancer, diabetes and Alzheimers, and about 25% of all pharmaceutical industry research and development is now focused on the discovery and evaluation of protein kinase inhibitors for therapeutic applications. |
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