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 (kī′nās′, -nāz′, kĭn′ās′, -āz′)
Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor protein. Kinases regulate many essential cellular processes.


(ˈkaɪneɪz; ˈkɪn-)
1. (Biochemistry) any enzyme that can convert an inactive zymogen to the corresponding enzyme
2. (Biochemistry) any enzyme that brings about the phosphorylation of a molecule
[C20: from kin(etic) + -ase]


(ˈkaɪ neɪs, -neɪz, ˈkɪn eɪs, -eɪz)

an enzyme that effects the transfer of a phosphate group from ATP to another molecule.
[1900–05; kin (etic) + -ase]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.kinase - an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
The NanoBRET TE platform combines the sensitivity of NanoLuc technology with quantitative capabilities of energy transfer, and allows for quantitative measurements of drug affinity and kinase selectivity inside live cells at target levels similar to that of endogenous kinases.
Summary: The PIM kinases are a family of serine/threonine kinases that catalyze the ATP dependent phosphorylation.
These include kinase inhibitors with activity against serine/threonine kinases, dual specificity kinases or both tyrosine and serine/threonine kinases being developed for oncological indications.
Summary: TEHRAN (FNA)- Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene.
Protein kinases are a large group of related enzymes that activate many kinds of proteins, thus mediating signal transduction in cell growth and differentiation.
Since their identification in the 1980s as having an important role in oncogenesis and tumor progression, protein kinases have received increasing attention as targets for anticancer drugs.
PI3 kinases regulate a variety of cellular functions, such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking.
Louis, Missouri, urban particles (UPs; Standard Reference Material 1648) on the constriction of isolated rat pulmonary artery tings and the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 mitogen-activated protein kinases (MAPKs) in human pulmonary artery endothelial cells with or without losartan, an antagonist of A[T.
Since receptor-binding Fn peptides decrease focal contacts, disturb cytoskeletal elements such as actin and decrease Fn receptor aggregation in fibroblasts, we have proposed that Fn-fs have similar effects in chondrocytes and that these changes in receptor and cytoskeletal elements alter the location of upstream kinases near receptors which leads to altered signal transduction and emergence of inflammatory MAP kinase pathways.
Defects in specific protein kinases have been linked to over 400 diseases including cancer, diabetes and Alzheimers, and about 25% of all pharmaceutical industry research and development is now focused on the discovery and evaluation of protein kinase inhibitors for therapeutic applications.
P38 MAP kinases are ubiquitously expressed not only in inflammatory cells, but in the liver, lungs, kidneys, heart, intestines, and other tissues.