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Related to Leukotrienes: Thromboxanes


Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

[leuko(cyte) + triene, a compound containing three double bonds (tri- + -ene).]


(Biochemistry) one of a class of products of metabolic conversion of arachidonic acid; the active constituents of slow-reacting substance, responsible for bronchial constriction, contraction of smooth muscle, and inflammatory processes
[C20: from leukocyte, in which they were discovered + triene from the conjugated triene unit that they contain]


or leu•co•tri•ene

(ˌlu kəˈtraɪ in)

a lipid, C20H30O3, produced by white blood cells in an immune response to antigens, that contributes to allergic asthma and inflammatory reactions.
[1975–80; leuko- + triene (see tri-, -ene)]
References in periodicals archive ?
Leukotrienes also can trigger cytokine synthesis, which can modulate leukotriene receptor function.
INV104 is a leukotriene receptor antagonist (LTRA) which works by blocking the action of leukotrienes in the lungs, thereby preventing inflammation and narrowing of the airways.
Taken orally, zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.
8) Montelukast blocks the interaction of cysteinyl leukotrienes with their receptors, there by inhibiting one of the inflammatory pathways in the pathogenesis of asthma.
Previous studies have shown that omega-3 fatty acids are associated with lower risks of cardiovascular disease outcomes, but a recent review (Prostaglandins, Leukotrienes & Essential Fatty Acids, online Sept.
Leukotrienes are involved in many inflammatory processes.
Leukotrienes formed by inflammatory cells are pro-inflammatory mediators, playing an important role in eosinophil recruitment and activation in EC.
Montelukast belongs to the class of medications called leukotriene receptor antagonists and works by blocking the action of leukotrienes, substances in the body that cause the symptoms of asthma and hayfever (allergic rhinitis).
It functions by blocking the act of leukotrienes, substances in the body that grounds the symptoms of asthma and hay fever (allergic rhinitis).
Here specialists consider asthma from such perspectives as the quality of asthma care within primary care, prostaglandins and leukotrienes as mediators of inflammation in asthma, series psychological distress and asthma, inhalation techniques associated with different devices used to treat asthma, nurse-led home visits for difficult asthma, and asthma therapy in elderly patients.
They stop leukotrienes in the body from constricting airways, from making mucus and from causing inflammation in the lungs.