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low-density lipoprotein

   Also found in: Medical, Encyclopedia, Wikipedia 0.37 sec.
low-density lipoprotein
n. Abbr. LDL
A complex of lipids and proteins, with greater amounts of lipid than protein, that transports cholesterol in the blood. High levels are associated with an increased risk of atherosclerosis and coronary heart disease.

low-density lipoprotein
A lipoprotein that contains relatively high amounts of cholesterol and is associated with an increased risk of atherosclerosis and coronary artery disease.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.low-density lipoprotein - a lipoprotein that transports cholesterol in the blood; composed of moderate amount of protein and a large amount of cholesterol; high levels are thought to be associated with increased risk of coronary heart disease and atherosclerosis
lipoprotein - a conjugated protein having a lipid component; the principal means for transporting lipids in the blood
LDL cholesterol - the cholesterol in low-density lipoproteins; the `bad' cholesterol; a high level in the blood is thought to be related to various pathogenic conditions

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Contrary to the accepted hypothesis positing downregulation of low-density lipoprotein receptor (LDLR) in humans, expression of the human APOE4 isoform combined with increased LDLR was harmful in genetically modified mice when red a high-fat Western diet, predicting important interactions between genotype/phenotype and exposure.
Most members of both groups initially had near-normal scores for low-density lipoprotein (LDL) cholesterol, the harmful kind.
At the end of the study, the walnut group had significantly lower total cholesterol as well as lower low-density lipoprotein levels (LDL, the bad cholesterol) as compared to the regular Mediterranean diet.
 
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