monoamine oxidase inhibitor

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Related to MAO inhibitors: serotonin, SSRI, Wellbutrin, tyramine, monoamine oxidase, Serotonin syndrome, Tricyclic antidepressants, COMT inhibitors

monoamine oxidase inhibitor

n. Abbr. MAOI
Any of a class of antidepressant drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamine neurotransmitters such as norepinephrine and serotonin.

monoamine oxidase inhibitor

n
(Biochemistry) biochem an agent that inhibits the action of monoamine oxidase. Such inhibitors are used in the treatment of depression. Abbreviation: MAOI

mon′oamine′ ox′idase inhib`itor


n.
any of various substances that block enzymatic breakdown of certain monoamine neurotransmitters and that are used to treat depression. Abbr.: MAOI
[1960–65]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulatemonoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
iproclozide - an antidepressant drug that acts as a monoamine oxidase inhibitor
isocarboxazid, Marplan - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
Nardil, phenelzine - monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
tranylcypromine - an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
References in periodicals archive ?
Patients who take nonselective MAO inhibitors need to be cautious with the foods they eat to prevent an abnormal build-up of tyramine, which could lead to an episode of extremely high blood pressure, potentially leading to stroke or heart attack.
Methylphenidate should not be taken by children with significant agitation; glaucoma; tics, family history or diagnosis of Tourette's syndrome; or current/recent use of MAO inhibitors (a type of antidepressant).
APLENZIN is contraindicated in patients who have a seizure disorder, patients being treated with Zyban(R) (bupropion HCl) Sustained-Release Tablets, WELLBUTRIN(R) (bupropion HCl), WELLBUTRIN SR(R) (bupropion HCl) Sustained-Release Tablets, or any other medications that contain bupropion, patients who have or had bulimia or anorexia nervosa, patients undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines), patients who have shown an allergic response to bupropion and patients taking MAO inhibitors.
MAO inhibitors may produce a hypertensive crisis when used in the presence of tocolytic agents and have been associated with congenital anomalies in animal studies.
Administration of tramadol may enhance the seizure risk in patients taking MAO inhibitors, neuroleptics, other drugs that reduce the seizure threshold, or in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections).
Drugs known to interact with MAO inhibitors were not allowed.
Regardless of whether selective serotonin reuptake inhibitors, tricyclic antidepressants, or MAO inhibitors are prescribed, complete abstinence from bingeing and purging occurs in only 20%-30% of treated patients.
The various trials' pharmacotherapy arms included treatment with tricycics, the selective serotonin reuptake inhibitor paroxetine, MAO inhibitors, lithium, and the amino acid tryptophan.
Fluvoxamine should not be used in combination with terfenadine, astemizole, cisapride, pimozide, or MAO inhibitors.
Still, in light of the side effects associated with MAO inhibitors and the fact that other antidepressants are not entirely ineffective, first-line treatment is with one of the newer antidepressants, particularly an SSRI.
Metadate(TM) ER Tablets should not be used with MAO inhibitors or for 14 days after stopping use of an MAO inhibitor.