monoamine oxidase inhibitor

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monoamine oxidase inhibitor

n. Abbr. MAOI
Any of a class of antidepressant drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamine neurotransmitters such as norepinephrine and serotonin.

monoamine oxidase inhibitor

n
(Biochemistry) biochem an agent that inhibits the action of monoamine oxidase. Such inhibitors are used in the treatment of depression. Abbreviation: MAOI

mon′oamine′ ox′idase inhib`itor


n.
any of various substances that block enzymatic breakdown of certain monoamine neurotransmitters and that are used to treat depression. Abbr.: MAOI
[1960–65]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulatemonoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
antidepressant, antidepressant drug - any of a class of drugs used to treat depression; often have undesirable side effects
iproclozide - an antidepressant drug that acts as a monoamine oxidase inhibitor
isocarboxazid, Marplan - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
Nardil, phenelzine - monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
tranylcypromine - an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
References in periodicals archive ?
Older medications for depression include tricyclics (Elavil, Pamelor) and MAO inhibitors (Nardil, Parnate), but these medications are rarely used, since the newer drugs are more effective and have fewer side effects for most patients.
Indeed, considering that various so-called MAO inhibitors can also interact with other AOs, we asked whether resveratrol, known to exert antioxidant activities, known to activate sirtuins [14, 15], and recently described to inhibit MAO [2, 16], was able to interact with SSAO, too.
Research on these natural substances manifests a need to find new and safe MAO inhibitors, and among such substances devoid of any serious side effects we can list Rhodiola rosea L.
It can also have interactions with various drug groups like SSRIs and MAO inhibitors to cause serotonin syndrome (2,3) and can present with tachycardia, hypertension, hyperthermia, agitation and even seizures, among other signs and symptoms.
Oral MAO inhibitors have proved at least as effective as cognitive-behavioral therapy or benzodiazepines for social phobia.
There are some contraindications to the use of MAO inhibitors, including severe liver and kidney impairment, severe or frequent headache, uncontrolled hypertension, cardiovascular diseases, and cerebrovascular diseases (Savinelli & Halpern 1995), but Brush et al.
MAO inhibitors in depression resistant to cyclic antidepressants: two controlled crossover studies with tranylcypromine versus L-5-hydroxytryptophan and nomifensine.
The four main categories of antidepressants are SSRI's, SNRI's, Tricyclics and MAO Inhibitors.
The mixture contains harmine, harmaline, and tetrahydroharmine, alkaloids that are also MAO inhibitors.
Because of this, ginseng has the potential to interact with many drugs, like anticoagulants, anticonvulsants, immunosuppressants, MAO inhibitors and oral anti-diabetic agents.
However, the most serious complication in the use of the combination of tryptophan and MAO inhibitors is the serotonin syndrome.
Caution should be exercised if BiDil is used with MAO inhibitors, alcohol, sildenafil, vardenafil or tadalafil.