In mammals, MHC polymorphism is maintained over long times by positive (balancing) selection at the nonsynonymous sites specifying the PBR of the MHC molecule
(Graser et al.
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule
Sometime along its treacherous evolutionary path, HCMV stole a class 1 MHC molecule
from its host and modified it for supreme stealth.
Characterization of peptides bound to the class I MHC molecule
We first considered the requirement that antigen-specific CTLs must respond to a peptide antigen exposed on the surface of APCs bound to a self class I MHC molecule
If an antigen receptor on a B-cell binds to a molecule on an antigen, the antigen will be internalized and a segment of the protein antigen will be presented by an MHC molecule
to a T-helper cell.
Completely unexpectedly, we found that one of the genes needing input from the eye in order to be expressed encodes an MHC molecule
," said Shatz.
In the newly discovered compartment that remained, enzymes began to break down the antigen, probably with an MHC molecule
standing by to grab the fragment it wants.
It snows that another type of MHC molecule
, MHC-II, does a similar job but in a different way, says Lawrence J.
Our understanding of the MHC molecule
has advanced enormously from this set of papers," says lan A.
In the current study, we determine effects of Dx on expression of mDC markers and MHC molecules
induced by 27OHChol, using THP-1 cells.
In the only benchmark performed so far and was trained on more than 110,000 quantitative binding data covering more than 100 different MHC molecules