After achieving remission, the presence of MRD
is the strongest prognostic factor for relapse in acute lymphoblastic leukemia.
Children are placed into 'low risk' or 'high risk' treatment regimes, based on whether the number of leukaemia cells detected by their MRD
test is above or below a single threshold.
The research has shown that combining the results of MRD
analysis with genetic profiling doctors will be able to significantly improve the accuracy of predicting relapse of the disease and improving treatment options.
Through this second collaboration, the companies will work towards further demonstrating the clinical utility of MRD
detection in patients with relapsed or refractory MM treated with Kyprolis.
It may be recalled that sixteen PPP workers were martyred during MRD
movement on September 29, 1983 at village Punhal Khan Chandio Taluka Sakrand in Shaheed Benazirabad district.
Like Kasturi Bhattacharjee et al, in this study, improvement in IPFH and MRD
was statistically as well as clinically significant.
The combination of BDO and MRD
is subject to customary closing conditions and is expected to be completed on November 1, 2016.
Following the transaction, shareholders of MRD
are expected to own approximately 31% of the outstanding shares of Range.
test can determine if a patient is in "molecular remission", which means there are no signs of the faulty molecules indicative of leukaemia cells in their blood.
The results were classified into three categories: good when MRD
was 3 mm, poor when MRD
was <1 mm, and fair with MRD
2 or 2.
Depending on the indication and practice setting, some laboratory MRD
testing is performed using nucleic acid assays (eg, BCRABL testing), and other MRD
testing is performed using flow cytometry; sometimes, both are performed.
Researchers hope the findings will expand use of MRD
measurements to guide leukemia treatment in children and adults.