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methotrexate
(redirected from MTX)

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
meth·o·trex·ate  (mth-trkst)
n.
A toxic antimetabolite, C20H22N8O5, that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases such as rheumatoid arthritis.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]

methotrexate [ˌmɛθəʊˈtrɛkseɪt ˌmiːθəʊ-]
n
(Medicine / Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5

methotrexate  (mth-trkst)
A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite


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Its manufacturers have released the findings of 83% of rheumatoid arthritis (RA) patients after two years compared to 66% of patients treated with a placebo and MTX.
MTX is also useful as an immunosuppressant and anti-inflammatory agent, even at low doses, and thus has potential in controlling recalcitrant psoriasis and adult rheumatoid arthritis, in long-term therapy.
CH-1504, a non-metabolized antifolate, is engineered to provide the same potent efficacy as MTX but without the side effects caused by the metabolic breakdown of MTX into by-products that are believed to play a significant role in the liver and kidney toxicities and tolerability related side effects associated with chronic therapy.
 
 
 
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