It could also aid superior understanding of the nature of episodic zoonotic epidemics such as those caused by Ebola virus, SARS CoV, Nipah virus, Machupo
virus, and hantaviruses that are still undiscovered.
Part II covers an overview of arenaviruses followed by major human pathogens, including Old World Lassa and Lujo viruses, and New World Junin, Machupo
, and Guanarito viruses, and cellular receptors of the latter, as well as hantaviruses, fioloviruses, and flviviruses, such as dengue, and, finally, yellow fever, and other flaviviruses with hemorrhagic potential during primary infections.
Tacaribe serocomplex viruses (family Arenaviridae, genus Arenavirus) comprise Bear Canyon virus, Tamiami virus, and Whitewater Arroyo virus in the United States; Tacaribe virus (TCRV) on Trinidad; Chapare virus (CHPV) and Machupo
virus (MACV) in Bolivia; Guanarito virus (GTOV) in Venezuela; Junin virus (JUNV) in Argentina; Sabia virus (SABV) in Brazil; and 9 other species (1).
Ebola, Marburg filoviruses and Lassa, Machupo
arenaviruses) Category B Brucellosis (Brucella species) Epsilon toxin of Clostridium perfringens Food safety threats (e.
Bugun icin tanimlanmis olan viral kanamali ates etkeni olan virusler KKKA'nin da etkeni olan Bunyaviridae, Filoviridae (Marburg virus ve Ebola virus), Arenaviridae (Lassa virus ve Junin, Machupo
, Sabia ve Guanarito virus), Rift Valley fever virus [RVFV] ve Hantavirus) ve Flaviviridae (yellow fever virus ve dengue virus) gibi RNA viruslandir (9).
In this study, the scientists first tested for yellow fever and Dengue hemorrhagic fevers, and Machupo
and other related viruses, with negative results.
The remaining ten pathogens (anthrax, smallpox, plague; tularemia, Ebola fever, Marburg fever, and the four South American viral hemorrhagic fevers: Guanarito, Junin, Machupo
, and Sabia) each cause specific skin outbreaks.
Looking back, it's interesting that during this same era, we witnessed the first major outbreak of the Ebola virus, machupo
plague, lassa fever, marburg disease, and of course here in the United States, legionnaires' disease.
Lassa, Ebola, Junin, Machupo
, and Marburg fevers are caused by different vira belonging to the family-filoviridae.
SIGA has antiviral programs targeting smallpox and other Category A pathogens, including arenaviruses (Lassa fever, Junin, Machupo
, Guanarito, Sabia, and lymphocytic choriomeningitis), dengue virus, and the filoviruses (Ebola and Marburg).
Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo
, and Guanarito.