FCX-013 is an autologous fibroblast genetically modified to express matrix metalloproteinase
1, a protein responsible for breaking down collagen.
Background: Matrix metalloproteinase
(MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs).
Furthermore, a difference in the gene for matrix metalloproteinase
(MMP2), an enzyme found in teeth, was linked to increased filling failure.
Normally the extracellular matrix and basement membrane is degraded by matrix metalloproteinase
-2 (MMP2), one of the most ubiquitous members of the matrix metalloproteinase
family, cleaves collagen type IV of the extracellular matrix maintaining equilibrium between matrix synthesis and degradation, thus providing a critical role in the cell integrity and cell survival (Malemud, 2006).
General overview of extracellular matrix metalloproteinase
structure is given in Figure 1 .
Longer wavelengths, including infrared light and visible light, have been shown to increase expression of matrix metalloproteinase
(MMP)--1 and -9, decrease expression of type 1 pro-collagen, and can induce macrophage infiltration.
Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase
The product is aimed at Membrane Type 1 Matrix Metalloproteinase
(MT1-MTP), which is highly expressed in many solid tumours, including triple negative breast cancer and non-small cell lung cancer.
Clinical and biochemical markers--including disease activity score, erythrocyte sedimentation rate, serum undercarboxylated osteocalcin (a bone metabolism marker that is elevated with low vitamin K status), C- reactive protein, and matrix metalloproteinase
, an enzyme that degrades collagens and other tissue components correlated with systemic inflammation of rheumatoid arthritis--were assessed before and after the treatment period.
Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase
Libert, "Is there new hope for therapeutic matrix metalloproteinase