included data from 760,729 participants who were followed for a range of 3 to 37 years.
We performed 2 analyses to address the issue: (a) an overall metaanalysis
of the 19 new studies and the 86 earlier publications to determine whether any effect was apparent when all available data were used, and (b) a "dose--response analysis" comparing IHD risk (TT vs CC) according to the differences between TT and CC individuals with respect to homocysteine concentration in each study.
Expedited" cataract surgery occurring within 4 weeks of diagnosis did not significantly reduce falls among elderly women, according to a metaanalysis
of two randomized controlled trials.
and his colleagues at the University of Hull (England), conducted a systematic review and metaanalysis
to examine the overall efficacy of bipolar-disorder-specific psychological therapies and the impact of previous episodes on its efficacy in relapse prevention (Bipolar Disord.
Vitamin D supplements of at least 400 international units (IUs) daily are associated with a reduced risk of bone fractures in older adults, according to results of a metaanalysis
published in the Archives of Internal Medicine, Mar.
There are also several studies suggesting folic acid may protect against certain pediatric cancers, and a recently reported metaanalysis
conducted by Motherisk found that prenatal vitamin use during pregnancy was associated with a reduced risk of some pediatric cancers.
of 19 randomized controlled trials (BMJ 2006 [Epub doi: 10.
In his article on meta-analysis, Saxton provides an explanation of metaanalysis
and briefly describes its application in LIS studies.
of results was not attempted given the differences in context, setting, and type of outcomes.
We hav done so by conducting a metaanalysis
of published comparisons between systems in which usability has been measured for both subjective preferences and objective performance.
By combining multiple studies, metaanalysis
can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes.