a biopharmaceutical company focused on developing therapies to augment the cytoprotective heme oxygenase metabolic pathway
, today announced the award of a Phase 1 Small Business Innovation Research (SBIR) grant from the National Institute of Neurological Diseases and Stroke (NINDS) of approximately $700,000 to fund further pre-clinical development of the Company's lead product candidate, HBI-002, for the treatment of acute cerebral injury.
Flux is the rate of turnover of molecules through a metabolic pathway
Following chapters introducing the main metabolic pathways
and metabolic regulation of bacterial cells, Shimizu (Kyushu Institute of Technology; Institute of Advanced Biosciences, Keio U, Tsuruoka, Japan) discusses the role of global regulators in response to the culture environment in metabolic regulation, conventional and 13-C metabolic flux balance analysis methods, their applications, and specific gene-knockout models in the study of metabolic pathway
Global Bioenergies demonstrates a novel metabolic pathway
enabling the direct conversion of renewable resources to propylene, one of the main building blocks of the petrochemical industry.
The Krebs cycle is the metabolic pathway
that takes carbohydrates, proteins, and fats and converts them into carbon dioxide and water to generate a usable form of energy for the body.
ZURICH -- The goal of individualized methotrexate therapy for psoriasis has drawn a big step closer as a consequence of a large pharmacogenetic study that identified polymorphisms in key genes in the drug's metabolic pathway
that are associated with increased likelihood of favorable response or toxicity.
treatment of psoriasis, Vitamin A Metabolic Pathway
The gene, named "PSR1", produces an enzyme which affects the metabolic pathway
of nitrogen, an essential source of nutrition for plants.
0 of pathSCOUT enables researchers to create interactive metabolic pathway
graphs on the fly, to integrate proprietary metabolic pathways
data with information from the public domain, and to make that combined information available to the entire organization.
Chapple's team planning to reroute the molecule that plants funnel into lignin production - the common amino acid phenylalanine - into an alternative metabolic pathway
to create phenylethanol, a combustible biofuel that could then be blended with gasoline, much like ethanol is now.
What we found was that mutations in the worm-equivalent of the APP gene slowed their development, which suggested that some metabolic pathway
was disrupted," said Professor Li.
The authors conclude that presystemic As metabolism is a significant process in the human body and that toxicokinetic studies aiming to fully elucidate the As metabolic pathway
might benefit from incorporating the metabolic potency of human gut microbiota, which might ultimately result in more accurate risk characterization of As exposures.