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 (mĭ-tăl′ə-prōt′n-ās′, -āz′, -prō′tē-nās′, -nāz′)
Any of a group of proteolytic enzymes whose catalytic activity depends on the presence of a metal ion in the active site, especially any of those (called "matrix metalloproteinases") that degrade proteins in the extracellular matrix.
References in periodicals archive ?
29) PRP also contains tissue inhibitors of metalloproteases (TIMP-1, TIMP-2, TIMP-3, and TIMP-4) and [sz]-thromboglobulin, which neutralizes the action of destructive metalloproteases.
sup][1],[2] Furthermore, matrix metalloproteases (MMPs) have the capacity to support the invasion of tumor cells by degrading almost all the components of the ECM and ECM proteins.
Different up-regulated proteins during the disease include insulin growth factor (IGF) II, a disintegrin and metalloproteases (ADAM) 9, signal transducers and activators of transcription (STAT) 3, suppressors of cytokine signalling (SOCS) 3, and cyclin D1 while the down-regulated proteins during the disease include collagen I, SMAD 4, fragile histidine triad (FHIT), and SOCS1.
19) were the first to demonstrate a reduction or an improvement in each of the following after aerobic exercise in patients with asthma: airway epithelial oxidative and nitrosative stress, Th2 cytokines, chemokines, adhesion molecules, anti-inflammatory effects, growth factors, and matrix metalloproteases.
First, an extract in buffer without inhibitors was designated as plain homogenate, second, an extract in buffer selective for metalloproteases [50 mM Tris-HCl pH 7.
Overactivity of Wnt signaling leads to stem cells constantly differentiating into osteoblasts, leading to osteophyte formation," he explained, noting that Wnt signaling also stimulates the secretion of cartilage-destroying metalloproteases (Osteoarthritis Cartilage.
tubiashii produces several potential virulence factors associated with its pathogenic capacity including extracellular metalloproteases and toxins such as hemolysins, cytotoxins, and siderophores (Hasegawa et al.
As stated, a number of disease states involve overexpression of matrix metalloproteases, and there exist diseases in which mutations result in overexpression of MMP-13 and premature development of osteoarthritis.
Purification and characterization of three novel keratinolytic metalloproteases produced by Chryseobacterium indologenes TKU014 in a shrimp shell powder medium.
As CD 10 has structural similarity to the matrix metalloproteases in the stroma, so it is believed that it affects invasion and metastatic potential of tumor cells by altering the cellular microenvironment.
Xeglyze Lotion, a topical formulation containing abametapir, an inhibitor of metalloproteases, has confirmed both ovicidal and lousicidal activity and provides the potential for a more effective treatment using only a single application.