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1. An alkylation process involving addition of, or substitution by, a methyl group.
2. The process of treating something with methyl alcohol.
References in periodicals archive ?
25) Furthermore, smoking may act indirectly on DNA methylation through inactivation of folate, vitamin B6 and vitamin Bi2, (26,27) which mediate 1-carbon transfers in the methylation pathway, and are critical for ensuring an appropriate balance in methylation capacity.
Higher arsenic methylation capacity is associated with lower risk for arsenical skin lesions, the classical sign of arsenic toxicity (Ahsan et al.
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Chronic neuroinflammation, with its associated oxidative stress, may therefore be an alternative explanation for both the observed reduction in methylation capacity and also the increase in P-tau; hypomethylation and hyperphosphorylation may not necessarily be directly causally related.
The less severely mutated embryos might rally their remaining methylation capacity to secure adequate methylation of the Igf-2 receptor gene, while somehow deeming other genes less important, he speculates.
The relative distribution of urinary arsenic metabolites varies from person to person and has been interpreted to reflect arsenic methylation capacity (Hopenhayn-Rich et al.
Cave outlined research documenting that children on the spectrum tend to have lower levels of methionine, S-adenosylmethionine, and total glutathionine; have impaired methylation capacity, and are at increased risk of oxidative stress.
As a result of the transfer of the methyl group, AdoMet is converted to S-adenosylhomocysteine (AdoHcy) and a decrease in the AdoMet/AdoHcy ratio is often taken as an indicator of reduced cellular methylation capacity (8-10).
2011) noted, and as we have previously reported (Gamble and Liu 2005), one implication of the observed association between uCr and As methylation capacity is that urinary As should not be expressed per gram creatinine to correct for urine concentration.
The AdoMet concentration and the AdoMet/AdoHcy ratio are indications for the methylation capacity.
Indeed, BD exposure induced profound DNA damage, especially the formation of N-7 guanine adducts, whose presence may profoundly compromise the methylation capacity of Dnmtl, as has been observed with other guanine adducts (Valinluck and Sowers 2007).
The influence of the M287T (T[right arrow]C) polymorphism in the AS3MT gene on the methylation capacity was much more pronounced in men than in women.