mitochondrial disease

(redirected from Mitochondrial encephalomyopathies)
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mitochondrial disease

n.
Any of various diseases caused by malfunctioning of mitochondria as a result of inherited or acquired mutations in mitochondrial or nuclear DNA, typically affecting several organ systems, especially the nervous and muscular systems.
References in periodicals archive ?
Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies.
The incidence of mitochondrial encephalomyopathies in childhood: Clinical features and morphological, biochemical, and DNA anbormalities.
One randomized, double-blind clinical trial that used a combination of creatine monohydrate, coenzyme Q10, and alpha-lipoic acid lowered markers of oxidative stress in people with mitochondrial cytopathies while creatine monohydrate used alone in patients with mitochondrial encephalomyopathies enhanced aerobic oxidative function of the mitochondria.
While childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions with fatal outcome, this syndrome stands out by showing complete (or almost complete) spontaneous recovery.
Studies on mitochondrial oxidative phosphorylation in permeabilized human skin fibroblasts: application to mitochondrial encephalomyopathies.
Leu(UUR)] gene associated with MELAS subgroup of mitochondrial encephalomyopathies.
Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies.
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