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(Physiology) a type of protein or cytokine that is developed from macrophagic or monocytic cells


(ˈmɒn əˌkaɪn)

a substance that is secreted by monocytes or macrophages in the immune response and that affects the function of other cells.
References in periodicals archive ?
Citing unpublished data from a postmortem study of 24 brains, Sherry Ferguson, PhD, research psychologist at the FDA National Center for Toxicology Research, said the brains of black patients studied had significantly higher levels of IL-1beta, TNF-related apoptosis-inducing ligand (TRAIL), and monokine induced by gamma interferon (MIG).
Austin, TX, USA) was used to measure the concentrations of interleukin- (IL-) 1[beta], IL-6, tumor necrosis factor- (TNF-) [alpha], interferon- (IFN-) [gamma], monokine induced by IFN-[gamma] (MIG), and IFN-[gamma]-induced protein- (IP-) 10 in the conjunctiva, as previously stated [32].
Interferon-[alpha], interferon-inducible protein 10, monokine induced by interferon-[gamma], IL-6, monocyte chemoattractant protein-1, and IL-8 were detected on day 11 of illness but levels decreased as the patient clinically improved (online Technical Appendix Figure 3, panel B).
12) IL-8 and the CXC chemokine, monokine induced by interferon gamma (Mig), seem to play an important role in the pathogenesis of VKC.
In contrast the monokine MIG, also involved in immune activity, was elevated.
The concentration of this monokine in umbilical blood serum of newborns of mothers with intrauterine infections had no significant differences from control values in the peripheral blood of healthy newborns; it made 179.
16) These data are well in line with the observation that in human PBMC, DMF inhibits lipopolysaccharide (LPS)-induced secretion of IL-8, monokine induced by IFN-[gamma] (Mig) and IP-10, all NF-[kappa]B dependent chemokines.
T cells, representing the adaptive arm of the immune response, also play a critical role in atherogenesis, entering lesions in response to the chemokineinducible protein-10, monokine induced by interferon (IFN)-[gamma], and IFN-inducible T cell [alpha]-chemo-attractant (31).
Table 2-3 Some Types of Cytokines and Their Functions Type Source Function Interleukin-1 Monokine produced by Activates B and activated macrophages T lymphocytes; mediates inflammation Interleukin-2 Lymphokine produced by Growth factor for B and helper T cells T lymphocytes; enhances cytotoxic effects of nonkiller (NK) cells Interferon Lymphokine produced by Activates macrophages; helper and suppressor promotes B- and T-cell T cells differentiation; activates neutrophils and NK cells Tumor necrosis Monokine produced by Mediator of inflammation factor activated macrophages Table 2-4 Phases of Acquired Immunity Phase Action Recognition Exposure to a specific antigen resulting in selective activation and expansion of those lymphocytes with antigenic receptors specific for that antigen.