NMDA receptor

(redirected from N-methyl-D-aspartate receptor)
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NMDA receptor

 (ĕn′ĕm′dē′ā′)
n.
A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease.

[N-m(ethyl)-d-a(spartate), an amino acid derivative that binds selectively to the receptor.]
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References in periodicals archive ?
N-methyl-D-aspartate receptors mediate Mesobuthus tamulus venom-induced vasosensory reflex responses in anesthetized rats.
Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California encephalitis project.
Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.
1999) Blockade of N-methyl-D-aspartate receptors in the insular cortex disrupts taste aversion and spatial memory formation.
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit.
Functional analysis of the proximal 5'-flanking region of the N-methyl-D-aspartate receptors subunit gene, NMDAR1.
Cloning and expression of the human N-methyl-D-Aspartate receptor subunit NR3A.
Sze Chun-I, Bi H, Kleinschmidt-Demasters BK, Filleybc CM, Martind LJ, N-methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease.
Suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuates responses to painful stimuli mediated through the N-methyl-D-aspartate receptor activation.
It acts on opioid receptors and is an N-methyl-D-aspartate receptor antagonist, it relieves neuropathic pain, has a long half-life, and can be administered every 6-8 hours.
The dual mode of action of Debio 9902 SR as a N-methyl-D-aspartate receptor antagonist and an AChE inhibitor, positions it as a third generation anti-Alzheimer's product by improving the general condition and cognitive functions of affected patients as well as having the potential of being a neuroprotectant.

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