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naltrexone |
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It was demonstrated in single dose studies for ELI-216 that no quantifiable blood levels of naltrexone hydrochloride were released at a limit of quantification ("LOQ") of 7. The study also helped determine the appropriate levels of naltrexone hydrochloride required to reduce or eliminate the euphoria experienced by subjects who might take crushed product to achieve a "high". ELI-216 is a controlled-release oxycodone hydrochloride agonist combined with an opioid antagonist, naltrexone hydrochloride, formulated to deter abuse of the drug. |
Naltrexone hydrochloride |
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