Summary: TEHRAN (FNA)- Gene expression in specific cells and in specific regions can provide a more precise, neuroprotective
approach than traditional treatments for neurological diseases.
Until now, many researchers have attempted to find neuroprotective
actions of medical plants and their components and studied their mechanisms of ischemia-induced neuronal death, such as glutamate-induced excitotoxicity, oxidative stress by excessive production of reactive oxygen species (ROS), and glial activation-mediated inflammatory response.
CDNF (Cerebral Dopamine Neutrophic Factor) is an endoplasmic reticulum located and secreted protein with neuroprotective
and neurorestorative properties.
Fortunately, many studies have demonstrated that in addition to controlling clinical symptoms, antidepressants, mood stabilizers, and atypical antipsychotics all have neuroprotective
effects, including stimulating neurogenesis, preventing apoptosis, and increasing neurotrophins.
Objective: The aim of the study was to investigate the neuroprotective
effects of p-tyrosol in the global cerebral ischemia-reperfusion (GC1) model.
Over 500 products have been investigated for neuroprotective
effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators and gene therapy.
Efforts are being made to develop neuroprotective
agents for recovery and prevention of further deterioration of brain tissues in patient with stroke.
Mind-NRG said it will use the funding to assess the mechanism of NRG-101a[euro](tm)s neuroprotective
effect in Parkinsona[euro](tm)s disease, seeking to advance the compound to proof-of-concept studies in patients.
effects of inhaled lavender oil on scopolamine-induced dementia via anti-oxidative activities in rats.
It is interesting to confirm the neuroprotective
effects mediated through M1 mAChR using PC12 cells, since PC12 cells as a common model to evaluate the neuroprotective
effects of certain compounds, endogenously express mAChRs, predominantly the M1 mAChR.
Purpose: The aim of our study was to investigate the neuroprotective
effects of topical (X-tocopherol in optic nerve crush model of rat and to compare its efficacy with that of systemic [alpha]-tocopherol.
We investigated the neuroprotective
effects of CoQ10 against Amyloid beta(25-35) (A[beta](25-35))-induced neurotoxicity in rat cortical neurons.