nondisjunction

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non·dis·junc·tion

 (nŏn′dĭs-jŭngk′shən)
n.
The failure of paired chromosomes or sister chromatids to separate and go to different cells during meiosis.

non′dis·junc′tion·al adj.

nondisjunction

(ˌnɒndɪsˈdʒʌŋkʃən)
n
(Genetics) the failure of paired homologous chromosomes to move to opposite poles of the cell during meiosis
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.nondisjunction - meiosis in which there is a failure of paired homologous chromosomes to separate; results in an abnormal number of chromosomes in the daughter cells
meiosis, miosis, reduction division - (genetics) cell division that produces reproductive cells in sexually reproducing organisms; the nucleus divides into four nuclei each containing half the chromosome number (leading to gametes in animals and spores in plants)
References in periodicals archive ?
3] Three different mechanisms can lead to triploidy: (i) a non-disjunction event in meiosis 1 or 2 of spermatogenesis; (ii) non-disjunction in meiosis 1 or 2 of oogenesis; and (iii) dispermy.
Finally, through non-disjunction some of the paired chromosomes representing paired linkage groups may not separate during synapsis and therefore more than the ordinary simplex number may be present in a portion of the mature germ cells.
The main cause of deterioration of oocyte quality is meiotic non-disjunction (20).
Investigations on Drosophila melanogaster indicated developed abnormalities due to the effect of mutagenic factors on meiotic chromosomal non-disjunction (Ramel, 2003).
The embryological etiology of DS is mainly correlated with the non-disjunction of a chromosome 21 during la maternal meiosis (4); this consists of errors occurring during the separation of homologous chromatid pairs.

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