pethidine

(redirected from Normeperidine)
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peth·i·dine

 (pĕth′ĭ-dēn′, -dən)

pethidine

(ˈpɛθɪˌdiːn)
n
(Pharmacology) a white crystalline water-soluble drug used as an analgesic. Formula: C15H21NO2.HCl. Also called: pethidine hydrochloride
[C20: perhaps a blend of piperidine + ethyl]
Translations

pethidine

[ˈpeθɪdiːn] Npetidina f

pethidine

n petidina, meperidina
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References in periodicals archive ?
The postulated mechanism of meperidine-associated seizures is related to its active metabolite normeperidine that has half of the activity of meperidine and a longer elimination half-life (8–12 h), therefore, cause excitation of the central nervous system and lead to nervousness, hyper-reflexia, myoclonus, and seizures.
Clearance of meperidine and its metabolite normeperidine in hemodialysis patients with chronic noncancer pain.
Meperidine is metabolized in liver to normeperidine, also excreted by kidneys.
Analyte Class Recovery % RSD (%) (N=4) Amphetamine Amphetamines 107% 3 MDEA 85% 4 MDMA 83% 4 Methamphetamine 102% 12 Buprenorphine Analgesics 87% 5 Tramadol 97% 9 Nordiazepam Benzodiazepines 106% 1 Temazepam 95% 2 Codeine Opiates 100% 10 Fentanyl Synthetic 100% 6 Meperidine Opiates 102% 9 Methadone 96% 2 Norfentanyl 82% 3 Normeperidine 101% 4 Propoxyphene 82% 9 Sufentanil 83% 11 Meprobamate Other 85% 7 Phencyclidine 100% 2
11) Normeperidine does not provide analgesia and is associated with neurotoxicity, including anxiety, tremor, muscle twitching, and seizure.
The active metabolite of merperidine, normeperidine, has an extended half-life, which is extended even longer in patients with CKD due to decreased renal elimination.
Normeperidine (a metabolite of meperidine) has a longer half-life than its parent molecule and, thus, will quickly accumulate to dangerous levels with repeated dosing, leading to adverse CNS stimulation.