reverse transcriptase inhibitor

(redirected from Nucleotide analogs)
Also found in: Thesaurus, Medical.

reverse transcriptase inhibitor

n. Abbr. RTI
Any of various antiviral compounds that interfere with the activity of the enzyme reverse transcriptase, which is found especially in retroviruses such as HIV. These compounds are divided into two classes: those that are nucleoside analogs (nucleoside reverse transcriptase inhibitors) and those that are not nucleoside analogs (non-nucleoside reverse transcriptase inhibitors).
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
NNRTI, non-nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
References in periodicals archive ?
The current hepatitis B market contains mainly nucleoside analog reverse transcriptase inhibitors, nucleotide analogs, and interferons.
The activation times of 2 chemical hot start polymerases (FastStart and Amplitaq Gold) and heat-activated nucleotide analogs (CleanAmp dNTPs) were assessed.
The authors also states that the nucleotide analogs, such as tenofovir are active in their native form.
Both nucleotide analogs and nucleoside analogs are reverse transcriptase inhibitors.
a company which pioneered the use of nucleotide analogs for the treatment of Hepatitis C virus (HCV), until its acquisition by Gilead Sciences, Inc.
Nucleotide analogs have shown the ability to deliver higher levels of the active triphosphate form of the drug into infected cells.
For platelets from both lean and obese study participants, we investigated (a) sensitivity to the antiaggregatory effects of the cyclic nucleotide analogs 8-pCPT-cAMP and 8-pCPT-cGMP on ADP-induced platelet aggregation; (b) PKA and PKG concentrations; and (c) concentrations of total VASP and of VASP phosphorylation in response to 8-pCPT-cAMP and 8-pCPT-cGMP.
The study, now appearing in the on-line edition of Nature Methods, demonstrates the synthesis and use of novel, fluorescently labeled, reversible terminator nucleotide analogs for use in single molecule DNA sequencing.
The use of DNA biotechnologies is often limited by which DNA polymerases recognize which modified nucleotide analogs," stated Dr.
TABLE 11 NUCLEOTIDE ANALOGS USED TO TREAT HEPATITIS 37
Berrey is a seasoned drug developer who has established a strong track record in antivirals, in particular with nucleotide analogs.
We are encouraged by the early efficacy and safety data being generated with our nucleotide analogs, PSI-7977 and PSI-938," stated Michelle Berrey, MD, MPH, Pharmasset's Chief Medical Officer.