reverse transcriptase inhibitor

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reverse transcriptase inhibitor

n. Abbr. RTI
Any of various antiviral compounds that interfere with the activity of the enzyme reverse transcriptase, which is found especially in retroviruses such as HIV. These compounds are divided into two classes: those that are nucleoside analogs (nucleoside reverse transcriptase inhibitors) and those that are not nucleoside analogs (non-nucleoside reverse transcriptase inhibitors).
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Noun1.reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
NNRTI, non-nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
References in periodicals archive ?
The current hepatitis B market contains mainly nucleoside analog reverse transcriptase inhibitors, nucleotide analogs, and interferons -
They describe the discovery of small molecule EPAC (exchange proteins directly activated by cAMP)-specific modulators by high-throughput screening; cyclic nucleotide analogs as pharmacological tools for studying signaling pathways; high-throughput FRET (fluorescence resonance energy transfer) assays for fast time-dependent detection of cyclic AMP in pancreatic beta cells; assessing cyclic nucleotide recognition in cells; and monitoring cyclic nucleotides using genetically encoded fluorescent reporters.
In addition to IFN, nucleotide analogs (NAs) are also currently approved for the treatment of HBV infection.
The activation times of 2 chemical hot start polymerases (FastStart and Amplitaq Gold) and heat-activated nucleotide analogs (CleanAmp dNTPs) were assessed.
Nucleoside and nucleotide analogs work by competitively inhibiting HBV DNA polymerase (reverse transcriptase).
Molecular biology reagents including Cyanine 3 and Cyanine 5 labeled fluorescent nucleotide analogs, and miRNA Chemical Labeling Kits.
Nucleotide analogs axe drugs that are structurally related to nucleotides.
The authors also states that the nucleotide analogs, such as tenofovir are active in their native form.
Both nucleotide analogs and nucleoside analogs are reverse transcriptase inhibitors.
The big worry with nucleotide analogs is nephrotoxicity.