Donald Kufe, MD, Dana-Farber Cancer Institute Targeting the MUC1-C oncoprotein
with new agents in drug resistant NSCLC
The fused oncoprotein
, because it directly regulates genes, leads to a series of further genetic changes in the cell," says Prof.
3) The association between the presence of HPV oncoprotein
E7 and the subsequent overexpression of the p16 protein by infected cells has led to the widespread use of immunohistochemical positivity for p16 as an indicator of HPV infection, particularly types 16 and 18.
Indeed, micro-array analysis has shown that HPV 16 E6 oncoprotein
regulates several genes involved in tissue differentiation and remodelling, which are important for inflammation and tumour progression.
Leica Bond Oracle HER2 IHC System is a semi-quantitative immunohistochemical (IHC) assay to determine HER2 (Human Epidermal Growth Factor Receptor 2) oncoprotein
status in breast cancer tissue processed for histological evaluation.
the chink, binding pocket of "functional significance" on the Ras oncoprotein
could provide the long-sought attack point for a therapeutic agent, making the "undruggable" Ras oncogene "druggable".
MGAH22, an Fc-modified monoclonal antibody, targets the HER2 oncoprotein
, which is overexpressed on the surface of various cancer cells and plays an important role in tumorigenesis, tumor aggressiveness, and outcome in breast and other cancers.
Some specific topics reported here include mimics of growth factors and cytokines, and peptide aptamers targeting the viral E6 oncoprotein
Interestingly the expression of Her-2 oncoprotein
was significantly reduced in the presence of ACE-c.
The human papillomavirus 16E7 oncoprotein
is able to bind to the retinoblastoma gene product.
Similar strategies have been used to screen signatures of FDA-approved compounds for ability to diminish EWS/FLI oncoprotein
abundance and thus tumor growth in Ewing sarcoma, (8) as well as to identify compounds that inhibit activation of the ERK pathway, which is often up-regulated in human tumours.
The chromosomal translocation results in a fusion between RAR [alpha] and another gene whose product is 'PML', generating a fusion product PML-RAR [alpha] , a chimaeric oncoprotein
that has been extensively studied over the last 10 years.