oncogene

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Related to Oncoprotein: Proto oncogenes

on·co·gene

 (ŏn′kə-jēn, ŏng′-)
n.
1. Any of various mutated genes that cause the transformation of normal cells into cancerous cells.
2. Any of various viral genes that transform host cells into cancerous cells.

[Greek onkos, mass, tumor; see oncology + gene.]

oncogene

(ˈɒŋkəʊˌdʒiːn)
n
(Genetics) any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
[C20 from Gk onkos mass, tumour + gene]

on•co•gene

(ˈɒŋ kəˌdʒin)

n.
any gene that is a causative factor in the initiation of cancerous growth.
[1965–70]

on·co·gene

(ŏn′kə-jēn)
A gene containing a mutation in its DNA that causes normal cells to turn into cancerous ones. See Note at cancer.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oncogene - a gene that disposes normal cells to change into cancerous tumor cellsoncogene - a gene that disposes normal cells to change into cancerous tumor cells
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Translations
References in periodicals archive ?
EMP2 is implicated as an oncoprotein in cancer biology and in addition to its overexpression associated with tumor-promoting activities in various tumor types, it has been shown to play a role in signaling migration and invasion of cancer stem cells.
Normally IDH1 and 2 converts isocitrate to a-KG (a-KG) but the mutated forms reduce a-KG to a new compound 2-hydroxyglutarate (2-HG), an oncoprotein involved in pathogenesis of leukaemia.
Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors.
14 Oncoprotein E6 causes the degradation of p53, causing the loss of p53 activity.
2010) Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization and pathophysiological action of the CagA oncoprotein.
The virulence of HPV is mainly exhibited by E6 and E7 encoded oncoprotein that cause low to high-grade cervical lesions (CIN-1, 2, 3), leading to cause 99.
We showed that EYA4 was negatively regulated by oncoprotein AML1-ETO at the mRNA level, suggesting that the down-regulation of EYA4 by AML1-ETO might contribute to accelerate the leukemogenesis of AML.
3,21) Therefore, the traditional gold standard for oncogenic HPV infection has been demonstration of transcriptionally active virus through detection of E6 and E7 viral oncoprotein messenger RNA with reverse-transcription PCR.
Therefore, the ITER-2 oncoprotein is a key target for treatment.
Transcription factor HIF1A [16] and MYC oncoprotein [17] are involved in upregulation of glucose transporters and many enzymes involved in glycolysis.
The translocation between chromosome 9 and 22 t (9,22) (q34;q11) leads to the formation of break point cluster region and Abelson's (BCR-ABL) a new hybrid fusion genes that encodes for an oncoprotein (P210) located in the cytoplasm that has a strong, capacity to activate tyrosine kinas resulting in the activation of several downstream signals that transform hematopoietic stem cells in to the leukemic cells, thus increased tyrosine kinas activity is currently thought to play a central role in the pathogenesis of CML [2].
10) On his initial colon biopsy, our patient had positive staining for the EBV oncoprotein, LMP1, which is frequently observed in HL.