methotrexate

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Related to Otrexup: methotrexate

meth·o·trex·ate

 (mĕth′ə-trĕk′sāt)
n.
A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]

methotrexate

(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
n
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5

meth•o•trex•ate

(ˌmɛθ oʊˈtrɛk seɪt)

n.
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Translations

methotrexate

n metotrexato, metotrexate m
References in periodicals archive ?
OTREXUP is being developed for self-administration of MTX to enhance the treatment of rheumatoid arthritis (RA), poly-articular-course juvenile RA and psoriasis.
President and CEO of Antares Pharma, commented, "The October approval and subsequent first quarter launch of OTREXUP to rheumatologists and dermatologists capped an incredibly successful year for our Company and our shareholders.
OTREXUP was developed for easy subcutaneous administration of MTX to enhance the treatment of rheumatoid arthritis (RA), poly-articular-course juvenile RA and moderate to severe psoriasis.