inhibitor

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Related to PDE inhibitor: phosphodiesterase type 5 inhibitors, PDE5

in·hib·i·tor

also in·hib·it·er  (ĭn-hĭb′ĭ-tər)
n.
One that inhibits, as a substance that retards or stops a chemical reaction.

inhibitor

(ɪnˈhɪbɪtə)
n
1. Also called: inhibiter a person or thing that inhibits
2. (Chemistry) Also called: anticatalyst a substance that retards or stops a chemical reaction. Compare catalyst
3. (Biochemistry) biochem
a. a substance that inhibits the action of an enzyme
b. a substance that inhibits a metabolic or physiological process: a plant growth inhibitor.
4. (General Physics) any impurity in a solid that prevents luminescence
5. (Astronautics) an inert substance added to some rocket fuels to inhibit ignition on certain surfaces

in•hib•i•tor

or in•hib•it•er

(ɪnˈhɪb ɪ tər)

n.
1. one that inhibits.
2. a substance that slows or stops a chemical reaction.
[1865–70]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.inhibitor - a substance that retards or stops an activity
substance - a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
angiotensin II inhibitor - an agent that retards or restrains the action of angiotensin II
antioxidant - substance that inhibits oxidation or inhibits reactions promoted by oxygen or peroxides
anticatalyst - (chemistry) a substance that retards a chemical reaction or diminishes the activity of a catalyst
moderator - any substance used to slow down neutrons in nuclear reactors
activator - (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription
Translations

in·hib·i·tor

n. inhibidor, agente que causa una inhibición;
fusion ______ de fusión.

inhibitor

n inhibidor m; angiotensin converting enzyme — inhibidor de la enzima convertidora de angiotensina; cholinesterase — inhibidor de la colinesterasa; fusion — inhibidor de (la) fusión; integrase — inhibidor de la integrasa; monoamine oxidase — inhibidor de la monoaminooxidasa; non-nucleoside reverse transciptase — (NNRTI) inhibidor no nucleósido de la transcriptasa inversa or reversa; nucleoside reverse transcriptase — (NRTI) inhibidor nucleósido de la transcriptasa inversa or reversa; nucleotide reverse transcriptase — (NtRTI) inhibidor nucleótido de la transcriptasa inversa or reversa; protease — inhibidor de la proteasa; proton pump — inhibidor de la bomba de protones; selective serotonin reuptake — inhibidor selectivo de la recaptación de serotonina
References in periodicals archive ?
m1] is the Michaelis constant for PDE activity, [I] is the concentration of PDE inhibitor, KI is the inhibitor dissociation constant, [k.
The reasons panelists gave for voting against approval included what some described as the "meager" or modest beneficial effect of roflumilast in studies, the need to compare it with other COPD treatments like theophylline (a nonspecific PDE inhibitor and the only PDE inhibitor marketed in the United States), and the need to evaluate its efficacy when added to standard COPD treatments like inhaled corticosteroids.
Moreover, as described in our PDE experiments, caffeine also act with weak affinity as PDE inhibitor and can also stimulate lipolysis in this way.
Optionally, the method includes administration of a type IV PDE inhibitor.
The rate was even higher for the PDE inhibitor Cialis, although the actual number of cases reported was small and the number of prescriptions was a fraction of Viagra's.
BOTHELL, Washington and INDIANAPOLIS, Indiana, February 10 /PRNewswire/ -- Lilly ICOS LLC (NYSE: LLY and Nasdaq: ICOS), marketer of Cialis(R) (tadalafil), a PDE5 inhibitor indicated for the treatment of erectile dysfunction (ED), is pleased with the European Patent Office's (EPO) final decision to affirm its earlier decision to revoke Pfizer's method-of-use patent - European Patent EP-B-0702555, containing claims for the use of any PDE inhibitor for the manufacture of an oral treatment for ED.
Cilomilast, which is pharmacologically related to theophylline, a nonspecific PDE inhibitor that is also used to treat COPD, is the first PDE-4 inhibitor to be reviewed by an FDA panel.
Phosphodiesterases (PDEs) are the enzyme superfamily of drug targets that underlie PDE inhibitor, Viagra(R), in 1998.
Lilly ICOS LLC , marketer of Cialis(R) (tadalafil), a PDE5 inhibitor indicated for the treatment of erectile dysfunction (ED), is pleased with the European Patent Office's (EPO) final decision to affirm its earlier decision to revoke Pfizer's method-of-use patent - European Patent EP-B-0702555, containing claims for the use of any PDE inhibitor for the manufacture of an oral treatment for ED.
The grant will fund research in collaboration with the University of Virginia to test the effectiveness of combining two potent anti-inflammatory drugs, ATL146e and a type IV PDE inhibitor in a drug eluting stent.
A pilot multi-center Phase II clinical study with the cGMP PDE inhibitor CP461, as a potential treatment for Crohn's disease, is currently underway at the University of Chicago Medical Center and other sites.