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Related to PTEN: p53, AKT, PI3K


abbreviation for


var. of deca- before a vowel: decathlon.


or Dec.,



1. deceased.
2. declension.
3. decrease.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Dec - the last (12th) month of the yearDec - the last (12th) month of the year  
Gregorian calendar, New Style calendar - the solar calendar now in general use, introduced by Gregory XIII in 1582 to correct an error in the Julian calendar by suppressing 10 days, making Oct 5 be called Oct 15, and providing that only centenary years divisible by 400 should be leap years; it was adopted by Great Britain and the American colonies in 1752
December 31, New Year's Eve - the last day of the year
Christmas Day, Dec 25, Xmas, Christmas - a Christian holiday celebrating the birth of Christ; a quarter day in England, Wales, and Ireland
Christmas, Christmastide, Christmastime, Noel, Yule, Yuletide - period extending from Dec. 24 to Jan. 6
Gregorian calendar month - a month in the Gregorian calendar
mid-December - the middle part of December
2.dec - (astronomy) the angular distance of a celestial body north or to the south of the celestial equator; expressed in degrees; used with right ascension to specify positions on the celestial sphere
astronomy, uranology - the branch of physics that studies celestial bodies and the universe as a whole
angular distance - the angular separation between two objects as perceived by an observer; "he recorded angular distances between the stars"
شَهْر كانون ثانٍ


abbr of DecemberDez.


abbr of deceasedgest.


written abbreviation
References in periodicals archive ?
PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer.
Penetrance of PTEN mutations is variable, the spectrum of associated clinical manifestations is large and diverse, and the hallmark skin lesions are subtle and easily missed.
Moreover, there is evidence indicated that PTEN is also expressed in vascular ECs and may serve as a viable target in therapeutic approaches to prevent vascular ECs apoptosis.
Immunohistochemical staining for PTEN was performed on 4-[micro]m unstained sections from the tissue microarray blocks by using a mouse monoclonal antibody against PTEN (6H2.
Based on this study, Abbott's FISH probes ability to detect the ERG/ETV1 gene and measure PTEN gene loss will be evaluated as part of scientific research starting some time later this year.
Therefore in the present study we looked for a relationship between F3 and HPSE expression in NSCLC tumors and investigated whether TF and heparanase are regulated by TP53, PTEN, and STK11.
The mutations occurred in a gene called DAF-18, which in mammals goes by the name PTEN.
They found the PTEN tumor suppressor gene in 20 patients (14%) overall; its presence was associated with endometrioid histology and more favorable survival, said Dr.
Contrary to what many oncologists had thought, a tumor suppressor protein known as PTEN does not reduce the effectiveness of the breast cancer drug Herceptin, according to a study by Mayo Clinic and North Central Cancer Research Group (NCCTG) investigators.
The tumor suppressor PTEN dephosphorylates the lipid second messenger, phosphoinositol 3,4,5-trisphosphate (PIP3), an enzymatic product PI3K, and negatively regulates survival signaling mediated by PI3K/Akt (PI3K/Akt) [13, 14].
Tumor suppressor gene PTEN can dephosphorylate the second messenger phosphatidylinositol-3-phosphate (PIP3) to PIP2, antagonizing the activity of PI3K/Akt signal pathway.