(redirected from PTEN)
Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to PTEN: p53, AKT, PI3K


abbreviation for


var. of deca- before a vowel: decathlon.


or Dec.,



1. deceased.
2. declension.
3. decrease.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Dec - the last (12th) month of the yearDec - the last (12th) month of the year  
Gregorian calendar, New Style calendar - the solar calendar now in general use, introduced by Gregory XIII in 1582 to correct an error in the Julian calendar by suppressing 10 days, making Oct 5 be called Oct 15, and providing that only centenary years divisible by 400 should be leap years; it was adopted by Great Britain and the American colonies in 1752
December 31, New Year's Eve - the last day of the year
Christmas Day, Dec 25, Xmas, Christmas - a Christian holiday celebrating the birth of Christ; a quarter day in England, Wales, and Ireland
Christmas, Christmastide, Christmastime, Noel, Yule, Yuletide - period extending from Dec. 24 to Jan. 6
Gregorian calendar month - a month in the Gregorian calendar
mid-December - the middle part of December
2.dec - (astronomy) the angular distance of a celestial body north or to the south of the celestial equator; expressed in degrees; used with right ascension to specify positions on the celestial sphere
astronomy, uranology - the branch of physics that studies celestial bodies and the universe as a whole
angular distance - the angular separation between two objects as perceived by an observer; "he recorded angular distances between the stars"
شَهْر كانون ثانٍ


abbr of DecemberDez.


abbr of deceasedgest.


written abbreviation
References in periodicals archive ?
Fresh metastatic tumor biopsies or archived surgical tumor biopsies, when available, were obtained and analyzed along with the circulating tumor cells (CTCs) in patients' blood for various genetic, proteomic, and morphological markers, including for the loss of the tumor suppressor PTEN gene.
Immunohistochemical staining for PTEN was performed on 4-[micro]m unstained sections from the tissue microarray blocks by using a mouse monoclonal antibody against PTEN (6H2.
When I was successful in obtaining mature human eggs from large, developed follicles after blocking PTEN activity, I gained confidence that this approach could work clinically.
But it had a big impact on tumour cells with a defective PTEN gene.
In the case of PTEN that could be disastrous, because as the researchers previously discovered, cutting PTEN protein levels by just 20 percent is enough to cause precancerous changes in mice.
Researchers experimenting on human prostate tissue and mice found that, in cells with normally functioning PTEN, sulphoraphane had no effect on cancer development.
Therefore in the present study we looked for a relationship between F3 and HPSE expression in NSCLC tumors and investigated whether TF and heparanase are regulated by TP53, PTEN, and STK11.
Results: PTEN alteration and NDRG1 expressions were significantly increased in the ischaemic area of endometrioid carcinoma compared with their expressions in the normal endometrium respectively (P<0.
Penetrance of PTEN mutations is variable, the spectrum of associated clinical manifestations is large and diverse, and the hallmark skin lesions are subtle and easily missed.
Of the 17 patients whose tumors were analyzed for PTEN status, 8 patients were shown to have reduced PTEN expression and 7 patients were shown to have absent PTEN expression.
Molecular aberrations in the phosphatidylinositol 3-kinase, or PI3K, pathway have been documented across cancers, especially mutations in the PIK3CA gene and mutation or loss of the tumor suppressor protein PTEN," explained Razelle Kurzrock, M.
But now, a new study led by scientists at The Scripps Research Institute (TSRI) shows how pseudogenes can regulate the activity of a cancer-related gene called PTEN.