Xu et al (25) also reported that HBsAg can suppress TLR9 transcription in plasmacytoid dendritic cells
Food and Drug Administration (FDA) for the treatment of blastic plasmacytoid dendritic cell
neoplasm (BPDCN), a rare and aggressive hematologic malignancy for which there is no effective treatment.
Plasmacytoid dendritic cells
activated by influenza virus and CD40L drive a potent TH1 polarization.
Circulating, interferon-producing plasmacytoid dendritic cells
decline during human aging.
Immunohistochemistry for CD123 demonstrated an increased number of plasmacytoid dendritic cells
His laboratory also discovered the human plasmacytoid dendritic cells
(pDCs), a novel cell type in the immune system that is specialized in anti-viral immune responses and implicated in the development of autoimmune diseases.
Induction of interferon-alpha production in plasmacytoid dendritic cells
by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
Then they detail such techniques as genomic DNA affinity chromatography to isolate interferon-inducible DNA binding factors, an inteferon-based cancer vaccine protocol applied to several types of murine cancers, and flow cytometric techniques to study plasmacytoid dendritic cells
in mixed populations.
The title of his abstract is "A novel class of host-derived etiological agent for autoimmunity: oligomers of endogenous proteins complex with self-nucleic acids and trigger Type I interferon production by plasmacytoid dendritic cells
The plasmacytoid dendritic cells
, although hardly recognized when present singly, tend to cluster, particularly at the margins of the necrotic foci (Figure 1, B).