Objective #3: New frontiers in cellular plasticity: chemical manipulation of cellular plasticity in vivo / new states of pluripotency
/ characterization of in vivo induced pluripotency
and its unique properties.
Once established in vitro, ESCs can be cultured indefinitely without losing their pluripotency
, and have the capacity to develop into any cell type in the body, and self-renewal (Okita and Yamanaka, 2006).
In February 2014, researchers claimed to have found a simple method of generating stem cells, by exposing adult cells to an acid bath; a method which they named stimulus-triggered acquisition of pluripotency
Based on ideas and concepts linking cell pluripotency
with metastatic and aggressive cancers, CureMeta is building a platform of potential cancer drug therapies through targeted antibody drug conjugates.
Asterias' core technologies center on stem cells capable of becoming all of the cell types in the human body, a property called pluripotency
But media attention soon grew into scepticism as doubts emerged about Obokata's papers on Stimulus-Triggered Acquisition of Pluripotency
The scientists say that mistakes in the work now make them question the existence of STAP cells, short for stimulus-triggered acquisition of pluripotency
The retraction states: "These multiple errors impair the credibility of the study as a whole and we are unable to say without doubt whether the stimulus-triggered acquisition of pluripotency
stem cells phenomenon is real.
STAP-SC stands for stem cells resulting from stimulus-triggered acquisition of pluripotency
In fact, one of the co-authors of the study had also called for a retraction in March, because he questioned some of the data that were used in the experiments, which led to the creation of so-called STAP cells (or stimulus-triggered acquisition of pluripotency
Transcription factor which is the pluripotency
genes (capable to differentiate into whatever cells needed by the damaged body) was estimated to be activated by Hypoxia Inducible Factor 2[alpha] (HIF 2[alpha]) after the initiation by Hypoxia Inducible Factor 1a (HIF 1[alpha]).
In particular, prolonged fasting reduced the enzyme PKA, an effect previously discovered by the Longo team to extend longevity in simple organisms and which has been linked in other research to the regulation of stem cell self-renewal and pluripotency
-- that is, the potential for one cell to develop into many different cell types.