Cadila Pharmaceuticals has recently emerged on the world map with the development of Polycap
- a novel and world's first drug combination for primary prevention of cardiovascular heart disease (CHD).
The concept is back in favour with an Indian generic manufacturer making the running (The Indian Polycap
Study, Lancet 2009; 373: 1341-1352).
Cadila Pharmaceuticals of Ahmedabad, India, has been testing the Polycap
, which contains three blood pressure medicines (atenolol, ramipril, and thiazide) plus a lipid-lowering drug (simvastatin) and one clot-altering medicine, a baby aspirin (100 mg) (10).
The Indian Polycap
Study (TIPS) enrolled people aged 45-80 years with a single CVD risk factor: type 2 diabetes, moderately elevated blood pressure (above 140/90 mm Hg but below 160/100 mm Hg), smoking within the prior 5 years, an LDL cholesterol above 3.
This article in the Lancet comes from the India Polycap
study, which examined the effects of the polypill--a combined statin, aspirin and folic acid with three blood pressure-lowering drugs (ramipril, atenolol and hydrochlorothiazide)--in middle-aged people without known cardiovascular disease.
Scientists compared Polycap
, a five-drug polypill, with combinations of its different components to assess effectiveness and safety.
Cadila's polypill is a capsule, with the brand name, Polycap
, dubbed the "polypill", includes a combination of statins, aspirin, a beta-blocker, ace inhibitor and a diuretic - medication already used individually to lower cholesterol and blood pressure, major cardiovascular disease risk factors.
In the trial led by Salim Yusuf at McMaster University in Hamilton, Canada, scientists tested the five-drug polypill - called Polycap
- in healthy individuals with one cardiovascular risk factor, such as being overweight, having smoked in the past five years, or having type-2 diabetes.
Scientists looked at Polycap
, a five-drug polypill, to assess effectiveness.
, a five-drug "polypill", contains aspirin to combat clotting, a cholesterol-lowering statin and three blood pressure-lowering drugs.
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