polymyxin

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Related to Polymyxins: colistin, Sulfonamides, Polyenes

pol·y·myx·in

 (pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

[New Latin polymyxa, specific epithet (poly- + Greek muxa, slime) + -in.]

polymyxin

(ˌpɒlɪˈmɪksɪn)
n
(Pharmacology) any of several polypeptide antibiotics active against Gram-negative bacteria, obtained from the soil bacterium Bacillus polymyxa
[C20: from New Latin Bacillus polymyxa; see poly-, myxo-, -in]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.polymyxin - any of several toxic antibiotics obtained from a particular soil bacterium
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
According to the company, the antibacterial class of polymyxins includes the drugs colistin and polymyxin B, essential antibiotics with potent activity against gram-negative pathogens, including E.
However, if treatment fails due to the development of resistance, these can be substituted with polymyxins (colistin and polymyxin B), sulbactam and tigeycycline19.
Polymyxins, aminoglycosides, and tigecycline have been used as core treatment drugs, considering local susceptibility patterns.
To the Editor: Infections caused by carbapenem-resistant Enterobacteriaceae have been associated with higher death rates than infections caused by carbapenem-susceptible strains, and resistant infections are mostly treated with polymyxins (1).
The mcr-1 gene confers resistance to the polymyxins, including the antibiotic colistin, a medication of last resort for multidrug-resistant infections.
Polymyxins first entered into clinical use in the 1950s but were not used for a long time because of their potential side effects, particularly nephrotoxicity.
coli) highly resistant to polymyxins, the last group ofantibioticsleft after all others have failed.
This gene, the researchers said, is widespread in bacteria known as EnterobacteriaceaeAaAaAeAeAaAeAeA -- a large family that includesAaAaAeAeAaAeAeA Salmonella, Esc coli,AaAaAeAeAaAeAeA Yersinia pestis,AaAaAeAeAaAeAeA KlebsiellaAaAaAeAeAaAeAeA andAaAaAeAeAaAeAeA Shigella resistance to a class of antibiotics known as polymyxins, which includes colistin that isAaAaAeAeAaAeAeA used as a drug of last res
The research on polymyxins A through E started back in 1947 and this class currently includes only two drugs of human use: polymyxin A and polymyxin E (colistin).
1 In view of increasing resistance of Acinetobacter to carbapenem, polymyxins have been considered an option for the treatment of multidrug resistant Acinetobacter spp.